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. Author manuscript; available in PMC: 2023 Feb 2.
Published in final edited form as: Org Biomol Chem. 2022 Feb 2;20(5):1041–1052. doi: 10.1039/d1ob02225c

Scheme 3.

Scheme 3.

Reagents and conditions: (a) KOAc, DMF, RT; (b) NH2OH·HCl, NaHCO3, MeOH, reflux, 79% for 2 steps; (c) 2, EDCI, HOBt, DCM, RT, 60%; (d) KOH (5 M), DMSO, RT, 90%; (e) Dess-Martin reagent, DCM, 0 °C-RT, 85% for 10, 88% for 11.