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Synthesis of radiotracers [18F]FS1P1. Reagents and conditions: (a) [18F]KF, Kryptofix 222, TMEDA, DMSO, H2O, 150 °C, 5 min; (b) β-alanine, AcOH, EtOH, 100 °C, 5 min; (c) NaCNBH3, RT, 2 min; (d) formalin, 100 °C, 5 min, then NaCNBH3, RT, 2 min; (e) β-alanine methyl ester, AcOH, EtOH, 100 °C, 5 min; (f) NaOH (5 M), 100 °C, 5 min, then AcOH for neutralization.
