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The topology of APP, Gpc-1, and α-SYN monomers (SYN) and filaments (SYNfil) associated with an endosomal lipid raft and possible fate of released heparan sulfate (HS) and SYN/SYNfil. β-Sec arrow, β-secretase cleavage site; HS, heparan sulfate chains; SH, thiol; SNO, S-nitrosothiol; HS-anMan, deaminatively released heparan sulfate, terminating with AM; β-CTF, C-terminal fragment of APP generated by β-secretase cleavage.
