TABLE 2.
The regulatory role of lncRNA in autophagy in the myocardial ischemia-reperfusion injury.
| LncRNA | Sources/Cells used | Expression level | Targeted genes | Autophagy related targets | Effects on autophagy | Related signaling pathways | Effects on MIRI | References |
|---|---|---|---|---|---|---|---|---|
| Neat 1 | SD rats | Up | — | Foxo1, Atg7, Atg5 | promotion | — | Upregulation of Neat1 aggravated the myocardial infarction size in diabetic myocardial tissue treated with I/R | Ma et al. (2018) |
| AK088388 | HL-1 | Up | miR-30a | Beclin-1, LC3 | promotion | — | Down-regulation of AK088388 weakened the autophagy during reperfusion and inhibited the myocardial cell death | Wang J. J. et al. (2019) |
| Neat 1 | C57BL/6 mice | Up | miR-378a-3p | Atg12 | Promotion | — | NEAT1 alleviated hypoxia-induced cardiomyocyte injury via miR-378-3p/Atg7 axis | Zhao et al. (2020) |
| PVT1 | AC16 | Up | miR-186 | Beclin-1 | Promotion | — | Knocking down PVT1 alleviated MIRI by inhibiting excessive autophagy | Ouyang et al. (2020) |
| HRIM | SD rats, H9c2 | Up | — | LC3 | Promotion | — | Inhibition of HRIM alleviated H/R induced injury by reducing excessive autophagy | Huang et al. (2018) |
| TTTY15 | C57BL6/J mice, H9c2, HL-1 | Up | miR-374a-5p | FOXO1 | Promotion | — | Down-regulation of TTTY15 alleviated MIRI by inhibiting autophagy | Chen et al. (2021) |
| CAIF | C57BL/6 mice | Down | P53 | myocardin | inhibition | — | Up-regulation of CAIF reduced the myocardial infarction size in the I/R hearts by inhibiting autophagy death | Liu et al. (2018) |
| APF | C57BL/6 mice | Up | miR-188-3p | ATG7 | promotion | — | Up-regulation of APF promoted autophagy and cell death and enlarged the area of myocardial infarction | Wang et al. (2015a) |
| FOXD3-AS1 | H9c2 | Up | — | ATG5, LC3II, Beclin1, p62 | Promotion | NF-κ B/COX2/iNOS | FOXD3-AS1 aggravated the H9C2 cell injury treated with I/R by promoting autophagy | Tong et al. (2019) |
| ANRIL | H9c2, SD rats | Down | — | LC3, Beclin-1 | Inhibition | — | Up-regulation of ANRIL alleviated MIRI by inhibiting myocyte autophagy | Han et al. (2021) |
| H19 | HL-1, C57BL/6 mice | Down | miR-143 | ATG7 | Promotion | — | Up-regulation of H19 triggered autophagy and alleviated H/R induced myocardial cell injury | Lv et al. (2021) |
| Galont | Mice | Up | miR-338 | ATG5 | Promotion | — | Up-regulation of Galont regulated ATG5, promoted autophagy, and aggravated the myocardial cell A/R injury | Yin et al. (2018) |
| PMRP | H9c2 | Up | miR-206 | ATG3 | Promotion | PI3K/AKT/mTOR | Up-regulation of RMRP aggravated MIRI by down-regulation of miR-206 and up-regulation of ATG3 | Kong et al. (2019) |
| MALAT1 | H9c2 | Up | miR-20b | Beclin1 | Promotion | — | Up-regulated MALAT1 enhanced the autophagy and promoted the OGD/R induced myocardial cell injury | Wang S. et al. (2019) |
| UCA1 | H9c2 | Down | miR-128 | HSP70 | Inhibition | — | Up-regulation of UCA1 reduced the myocardial autophagy and apoptosis induced by myocardial I/R injury | Chen et al. (2018) |
| XIST | H9c2 | Up | miR-133a | LC3, SOCS2 | Promotion | — | Inhibition of XIST improved MIRI by inhibiting autophagy and regulating SOCS2 | Li et al. (2019) |
| AK139328 | C57BL/KsJ db/+ mice | Up | miR-204-3p | Atg7, Atg5, LC3, p62 | Promotion | — | Silencing AK139328 alleviated MIRI in diabetic mice | Yu et al. (2018) |
| Dancr | H9c2 | Down | miR-6324 | Beclin-1, LC3 | Inhibition | IRE1α/Xbp1 | Up-regulated Dancr promoted autophagy and protected cardiomyocytes from ER stress injury | Li J. et al. (2021) |
| TUG1 | C57BL/6J wild-type mice, HACMs | Up | miR-142-3p | HMGB1, Rac1 | Promotion | — | Targeting TUG1 ameliorated myocardial I/R injury | Su et al. (2019) |