TABLE 3.

The regulatory role of circRNA in autophagy in the myocardial ischemia-reperfusion injury.

CircRNA	Sources/Cells used	Expression level	Targeted miRNA	Autophagy related targets	Effects on autophagy	Related signaling pathways	Effects on MIRI	References
circHIPK3	C57BL/6J mice, NMVCs	Up	miR-20b-5p	ATG5	promotion	—	Up-regulation of circHIPK3 promoted autophagy and apoptosis, and aggravated myocardial cell injury	Qiu et al. (2021)
circ_0000064	Wistar rats	Down	—	P62, LC3, Beclin-1	inhibition	—	Up-regulation of circ_0000064 improved MIRI by inhibiting autophagy and apoptosis	Jin et al. (2021)
ACR	C57BL/6 mice	Up	—	Pink1	inhibition	Pink1/FAM65B	Overexpression of ACR alleviated MIRI by inhibiting autophagy and cell death	Zhou et al. (2019)
circPAN3	C57BJ/6L mice, HCMs, HEK293	Down	miR-421	Pink1	inhibition	—	Overexpression of circPAN3 inhibited autophagy and improved MIRI	Zhang et al. (2021)