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. 2022 Apr 1;132(7):e152069. doi: 10.1172/JCI152069

Figure 2. In vivo reprogramming using ATOH1 in p53-deficient cells enables development of full-blown murine MCC.

Figure 2

(A) Addition of conditional Trp53 allele to generate SLAP mice expressing MCPyV sTAg, tLTAg, and ATOH1, which are also deficient in p53, in Krt5-expressing cells and their progeny. (B) Gross tumor arising in SLAP mouse 4 months after transgene induction. (C) Similar histopathology of SLAP mouse tumor and human MCC. Immunostaining for (D) transgene expression and (E) MCC marker expression. Scale bars: 25 μm.