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. 2022 Apr 1;132(7):e156507. doi: 10.1172/JCI156507

Figure 1. Anti-CD45RC mAb treatment controls the development of autoimmune lesions in Aire–/– rats.

Figure 1

(A) Schematic of the protocol of administration of isotype control or anti-CD45RC mAbs as prevention in 3-week-old Aire–/– rats. (B) Representative photographs of Aire–/– rats after 4 months of treatment with either isotype control (n = 13) or anti-CD45RC mAbs (n = 13). Arrows indicate the alopecia- and vitiligo-like manifestations. Scale bars: 5 cm. (C) Evolution of weight gain in Aire–/– male rats during treatment with isotype control (n = 6) or anti-CD45RC mAbs (n = 6) until sacrifice. ANOVA comparing curves: ***P < 0.001. (D) Representative pictures of H&E histological analysis of organs from Aire–/– rats at the end of the 4-month treatment with isotype control (n = 7) or anti-CD45RC mAbs (n = 7). Black arrows indicate lesions and mononuclear cell infiltrates. Black bars indicate the marginal zone. Scale bars: 250 nm (thymus and spleen), 500 μm (skin and kidney), and 1 mm (pancreas and lung).