Table 4.

Salivary mediator levels

	HC (n = 10)	Grade B periodontitis (n = 5)	Grade C periodontitis (n = 25)	p
IL-1β (pg/mL)	0.00 [0.00–1.38]	8.50 [6.00–12.75]∗	12.25 [8.00–21.63]∗	<0.001
IL-6 (pg/mL)	0.00 [0.00–0.00]	0.00 [0.00–1.00]	0.50 [0.00–1.50] †	0.013
MMP-8 (pg/mL)	431.50 [182.00–1385.00]	1257.50 [805.00–1617.50]	1125.00 [803.75–1630.00]	0.057
IL-10 (pg/mL)	0.00 [0.00–0.38]	1.50 [0.00–3.00]	0.00 [0.00–1.88]	0.155

Data summarized as median and interquartile range (IQR); p value derived from the Kruskal–Wallis test and Mann–Whitney U test. ^∗Significant difference from the HC group (p ≤ 0.01). ^†Significant difference from the HC group (p < 0.05). HC: healthy control.