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. 2022 Apr 1;78:103978. doi: 10.1016/j.ebiom.2022.103978

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 1 — Age-dependent T-cell telomere length (TL) and its relation to T-cell clonal expansion. (a) displays age-dependent TL before () and after () clonal expansion. Naïve T-cell clonal expansion shortens telomeres by Δ, where Δ_max is T-cell telomere shortening resulting from expansion to form the maximal clonal size (MCS). The telomeric brink (TL_B) of 5 kb is TL that increases the risk of cessation of replication. TL₂₀ is TL at 20 years, TL_O is telomeric onset, which indicates the shortest T-cell TL that enables attaining MCS. X_O is age of onset of clonal expansion limitation. (b) displays T-cell clonal expansion size vs age from X_O. Circle areas depict relative clonal size at and after X_O. Light blue circle is MCS.

Inline graphic — Age-dependent T-cell telomere length (TL) and its relation to T-cell clonal expansion. (a) displays age-dependent TL before () and after () clonal expansion. Naïve T-cell clonal expansion shortens telomeres by Δ, where Δ_max is T-cell telomere shortening resulting from expansion to form the maximal clonal size (MCS). The telomeric brink (TL_B) of 5 kb is TL that increases the risk of cessation of replication. TL₂₀ is TL at 20 years, TL_O is telomeric onset, which indicates the shortest T-cell TL that enables attaining MCS. X_O is age of onset of clonal expansion limitation. (b) displays T-cell clonal expansion size vs age from X_O. Circle areas depict relative clonal size at and after X_O. Light blue circle is MCS.