Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 1;78:103978. doi: 10.1016/j.ebiom.2022.103978

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig 4 — Steps linking mean limited clone size (LCS) to COVID-19 mortality and general mortality hazards ratios₂₀ in the population. (a) displays data based on COVID-19 mortality () and non-COVID-19 mortality (), and corresponding exponential fitted relationships for hazards ratios₂₀ ( and ). (b) displays the relationship of mean LCS in units of 10⁶ cells with age, generated with Eq. 2, using the TL₂₀ distribution of Figure 2a. (c) displays the relationships of hazards ratios₂₀ generated from COVID-19 mortality and non-COVID-19 mortality plotted against mean LCS obtained from Figure 4b. The top of the panel also displays age. The divergence between the COVID-19 and non-COVID-19 mortalities occurs at mean LCS of ∼ 0.13×10⁶ T cells. At the corresponding age, 50 years, the population is about evenly divided into the LCS and MCS groups (Figure 3b). After this age, increased proportion of the population is in the LCS group, which is susceptible to COVID-19 mortality, whereas the MCS group is not.

Inline graphic — Steps linking mean limited clone size (LCS) to COVID-19 mortality and general mortality hazards ratios₂₀ in the population. (a) displays data based on COVID-19 mortality () and non-COVID-19 mortality (), and corresponding exponential fitted relationships for hazards ratios₂₀ ( and ). (b) displays the relationship of mean LCS in units of 10⁶ cells with age, generated with Eq. 2, using the TL₂₀ distribution of Figure 2a. (c) displays the relationships of hazards ratios₂₀ generated from COVID-19 mortality and non-COVID-19 mortality plotted against mean LCS obtained from Figure 4b. The top of the panel also displays age. The divergence between the COVID-19 and non-COVID-19 mortalities occurs at mean LCS of ∼ 0.13×10⁶ T cells. At the corresponding age, 50 years, the population is about evenly divided into the LCS and MCS groups (Figure 3b). After this age, increased proportion of the population is in the LCS group, which is susceptible to COVID-19 mortality, whereas the MCS group is not.