TABLE 2.
Longitudinal changes in maternal and neonatal iron status1
| Trimester 2 (visit 1: 57Fe dose) | Trimester 3 (visit 4: 58Fe dose) | Delivery | Neonate | |
|---|---|---|---|---|
| Gestational age, wk | 15.0 ± 0.7 | 34.0 ± 0.7 | 39.4 ± 1.8 | 39.4 ± 1.8 |
| n | 15 | 13 | 15 | 15 |
| Weight, kg | 68.9 ± 21.2a | 77.7 ± 18.8b | 79.9 ± 20.7c | 3.4 ± 0.3 |
| Hemoglobin, g/dL | 12.2 ± 1.9 | 11.0 ± 1.3 | 11.6 ± 1.2 | 13.7 ± 2.3 |
| Anemia, % | 7a | 54b | 23a | 33 |
| Serum ferritin, ug/L | 50.1 [30.6, 82.2]a | 22.7 [12.1, 42.8]b | 33.8 [17.6, 64.6]c | 205.8 [141.5, 299.3] |
| Serum ferritin <12 ug/L, % | 7 | 25 | 8 | — |
| Transferrin receptor, mg/L | 3.6 [2.6, 5.0]a | 4.9 [3.6, 6.6]b | 5.3 [3.83, 7.4]c | 6.2 ± 1.8 |
| Total body iron, mg/kg | 8.0 ± 3.4a | 4.0 ± 3.5ab | 5.2 ± 4.1b | 11.3 ± 3.0 |
| Erythroferrone, ng/mL | 0.7 [0.4, 1.5] | 0.8 [0.4, 1.7] | 0.7 [0.4, 1.3] | 1.6 [0.8, 3.3] |
| Erythropoietin, mIU/mL | 18.5 [12.4, 27.7]a | 30.4 [17.6, 52.3]b | 29.5 [16.3, 53.2]a | 27.4 [16.6, 45.0] |
| Hepcidin, ng/mL | 10.8 ± 7.5 | 5.4 ± 5.1 | — | 36.0 ± 18.1 |
| Undetectable hepcidin, % | 7 | 0 | — | 0 |
1
Data are presented as mean ± SD for normally distributed data or geometric mean [95% CI] for nonnormally distributed data. Values with different superscripts within a row significantly differ from one another, P < 0.05. Neonatal iron status was determined using umbilical cord blood. Undetectable hepcidin was classified as values <0.39 ng/mL.