Table 1.
List of cellular metabolites significantly differentiating cell lines harboring HMP from LMP
| Metabolite | Pathway | Sub-pathway | FC | FDR |
|---|---|---|---|---|
| N-acetylalanine | Amino Acid | Alanine Metabolism | 1.58 | 5.57 × 10–6 |
| Gamma-carboxyglutamate | Glutamate Metabolism | 2.71 | 3.04 × 10–9 | |
| 4-Hydroxyglutamate | 4.50 | 9.47 × 10–4 | ||
| Beta-citrylglutamate | 5.51 | 3.38 × 10–4 | ||
| Glutamate gamma-methyl ester | 5.54 | 4.05 × 10–3 | ||
| Cysteinylglycine | Glutathione Metabolism | 1.99 | 4.93 × 10–4 | |
| S-lactoylglutathione | 5.58 | 4.03 × 10–4 | ||
| N-acetylglycine | Glycine Metabolism | 2.66 | 5.06 × 10–3 | |
| 4-Imidazoleacetate | Histidine Metabolism | 5.18 | 1.87 × 10–3 | |
| 3-Methyl-2-oxovalerate | BCAA Metabolism | 2.16 | 2.36 × 10–3 | |
| 4-Methyl-2-oxopentanoate | 2.77 | 1.71 × 10–3 | ||
| 3-Methyl-2-oxobutyrate | 4.64 | 9.40 × 10–6 | ||
| Lanthionine | Methionine Metabolism | 0.34 | 1.77 × 10–3 | |
| Methionine sulfoxide | 0.59 | 1.18 × 10–4 | ||
| N-formylmethionine | 1.74 | 1.09 × 10–5 | ||
| Spermidine | Polyamine Metabolism | 0.42 | 8.56 × 10–11 | |
| 5-Methylthioadenosine (MTA) | 1.63 | 3.54 × 10–3 | ||
| Kynurenine | Tryptophan Metabolism | 0.10 | 4.33 × 10–6 | |
| Serotonin | 2.48 | 3.48 × 10–4 | ||
| O-methyltyrosine | Tyrosine Metabolism | 0.65 | 5.70 × 10–6 | |
| Citrulline | Urea cycle metabolism | 0.58 | 6.17 × 10–4 | |
| N-acetylglucosamine/N-acetylgalactosamine | Carbohydrate | Aminosugar Metabolism | 0.49 | 6.06 × 10–4 |
| Erythronate | 2.98 | 9.05 × 10–6 | ||
| Fructose | Fructose & Mannose Metabolism | 2.97 | 9.25 × 10–8 | |
| Mannose-6-phosphate | 7.36 | 3.04 × 10–9 | ||
| 3-Phosphoglycerate | Glycolysis/Gluconeogenesis | 2.04 | 1.09 × 10–5 | |
| Phosphoenolpyruvate | 2.06 | 1.96 × 10–5 | ||
| Fructose 1,6-2D/glucose 1,6-2P/myo-inositol-2P | 2.29 | 5.71 × 10–3 | ||
| 2-phosphoglycerate | 2.97 | 3.04 × 10–9 | ||
| Glucose 6-phosphate | 4.16 | 2.39 × 10–9 | ||
| Fructose-6-phosphate | 6.68 | 3.97 × 10–6 | ||
| UDP-glucose | Nucleotide Sugar | 1.80 | 2.91 × 10–3 | |
| UDP-galactose | 2.02 | 1.92 × 10–3 | ||
| Ribonate | Pentose Phosphate | 2.63 | 1.77 × 10–3 | |
| 6-phosphogluconate | 5.22 | 4.27 × 10–8 | ||
| Nicotinamide adenine dinucleotide | Cofactors and Vitamins | Nicotinamide Metabolism | 1.80 | 2.51 × 10–4 |
| Nicotinamide adenine dinucleotide R | 1.89 | 1.16 × 10–3 | ||
| Phosphopantetheine | Pantothenate Metabolism | 0.32 | 1.56 × 10–3 | |
| Coenzyme A | 1.78 | 3.59 × 10–4 | ||
| Thiamin (Vitamin B1) | Thiamine Metabolism | 1.84 | 3.21 × 10–4 | |
| Thiamin diphosphate | 3.64 | 9.05 × 10–6 | ||
| Citrate | Energy | TCA Cycle | 1.54 | 8.28 × 10–11 |
| Aconitate [cis or trans] | 1.73 | 2.08 × 10–6 | ||
| Malate | 1.79 | 1.80 × 10–5 | ||
| Isocitrate | 1.89 | 4.01 × 10–3 | ||
| Alpha-ketoglutarate | 3.03 | 9.25 × 10–8 | ||
| 2-methylcitrate/homocitrate | 4.03 | 3.69 × 10–7 | ||
| Succinylcarnitine | 9.09 | 1.45 × 10–7 | ||
| Ceramide (d18:1/14:0 d16:1/16:0) | Lipid | Ceramides | 0.43 | 5.73 × 10–3 |
| Myristoyl dihydrosphingomyelin | Dihydrosphingomyelins | 0.21 | 6.38 × 10–4 | |
| N-linoleoyltaurine | Endocannabinoid | 0.55 | 2.83 × 10–3 | |
| Palmitoyl ethanolamide | 0.48 | 7.61 × 10–3 | ||
| Propionylcarnitine | Fatty Acid Metabolism (Acyl Carnitine) | 7.88 | 1.10 × 10–4 | |
| Acetylcarnitine | 2.90 | 5.37 × 10–7 | ||
| Linoleoylcarnitine (C18:2) | 0.15 | 9.40 × 10–6 | ||
| Myristoleoylcarnitine (C14:1) | 0.37 | 1.43 × 10–5 | ||
| Oleoylcarnitine (C18:1) | 0.20 | 2.36 × 10–3 | ||
| Palmitoleoylcarnitine (C16:1) | 0.23 | 3.80 × 10–03 | ||
| Glycerophosphoglycerol | Glycolipid Metabolism | 4.64 | 9.05 × 10–6 | |
| Galactosylglycerol | 4.61 | 3.76 × 10–3 | ||
| 1-Linoleoyl-GPE (18:2) | Lysophospholipid | 4.83 | 1.15 × 10–6 | |
| 2-Stearoyl-GPE (18:0) | 3.72 | 1.86 × 10–6 | ||
| 1-Linoleoyl-GPC (18:2) | 1.94 | 2.98 × 10–6 | ||
| 1-Stearoyl-GPE (18:0) | 2.64 | 4.64 × 10–6 | ||
| 1-Oleoyl-GPE (18:1) | 1.79 | 1.64 × 10–4 | ||
| 1-Stearoyl-GPI (18:0) | 0.48 | 6.06 × 10–4 | ||
| 1-Stearoyl-GPC (18:0) | 5.90 | 2.91 × 10–3 | ||
| 1-Palmitoyl-GPI (16:0) | 0.55 | 2.95 × 10–3 | ||
| 1-Arachidonoyl-GPE (20:4n6) | 1.62 | 7.69 × 10–3 | ||
| 1-Stearoyl-GPG (18:0) | 2.34 | 8.40 × 10–3 | ||
| 1-Oleoylglycerol (18:1) | Monoacylglycerol | 0.10 | 5.33 × 10–3 | |
| 1-Myristoyl-2-arachidonoyl-GPC (14:0/20:4) | Phosphatidylcholine | 0.49 | 3.16 × 10–4 | |
| 1-Stearoyl-2-oleoyl-GPG (18:0/18:1) | Phosphatidylglycerol | 2.91 | 1.64 × 10–5 | |
| Choline phosphate | Phospholipid Metabolism | 1.90 | 4.90 × 10–5 | |
| Choline | 0.62 | 1.77 × 10–3 | ||
| Sphingadienine | Sphingolipid Synthesis | 2.39 | 7.73 × 10–7 | |
| Phytosphingosine | 1.90 | 8.40 × 10–4 | ||
| Sphingosine | Sphingosines | 1.97 | 2.33 × 10–7 | |
| AICA ribonucleotide | Nucleotide | Purine Metabolism | 18.26 | 4.36 × 10–5 |
| 2′-deoxyadenosine 5′-triphosphate | 2.93 | 3.90 × 10–4 | ||
| 2′-deoxyadenosine 5′-diphosphate | 5.67 | 1.51 × 10–7 | ||
| Guanosine 5′-triphosphate | 1.53 | 4.36 × 10–5 | ||
| Guanosine 5′- diphosphate | 1.79 | 5.65 × 10–6 | ||
| Guanine | 4.17 | 5.80 × 10–3 | ||
| Cytidine 2′3′-cyclic monophosphate | Pyrimidine Metabolism | 0.09 | 4.41 × 10–11 | |
| Cytidine 5′-monophosphate | 2.89 | 3.42 × 10–3 | ||
| Orotate | 1.59 | 9.34 × 10–4 | ||
| Dihydroorotate | 1.64 | 7.65 × 10–3 | ||
| Orotidine | 4.93 | 9.63 × 10–4 | ||
| 3-Ureidopropionate | 2.48 | 1.90 × 10–5 | ||
| 4-Methylbenzenesulfonate | Xenobiotics | Chemical | 0.27 | 7.16 × 10–3 |
| Gluconate | Food Component/Plant | 3.60 | 2.43 × 10–4 |
Times symbol indicate nicotinamide adenine dinucleotide reduced (NADH)