Table 2.
List of growth medium metabolites significantly differentiating cell lines harboring HMP from LMP
| Metabolite | Pathway | Sub-pathway | FC | FDR |
|---|---|---|---|---|
| Guanidinoacetate | Amino Acid | Creatine Metabolism | 0.39 | 1.35 × 10–3 |
| 2-Hydroxy-3-methylvalerate | BCAA Metabolism | 3.62 | 1.19 × 10–13 | |
| Alpha-hydroxyisocaproate | 4.08 | 2.30 × 10–6 | ||
| 1-Carboxyethylleucine | 0.66 | 9.39 × 10–5 | ||
| 4-Methyl-2-oxopentanoate | 2.77 | 4.91 × 10–4 | ||
| 3-Methyl-2-oxobutyrate | 2.19 | 5.88 × 10–4 | ||
| 3-Methyl-2-oxovalerate | 2.44 | 6.46 × 10–4 | ||
| Ethylmalonate | 0.49 | 2.89 × 10–3 | ||
| Cystathionine | Methionine Metabolism | 0.57 | 1.92 × 10–3 | |
| Kynurenine | Tryptophan Metabolism | 0.12 | 1.51 × 10–5 | |
| 3-Hydroxyhexanoate | Lipid | Fatty Acid, Monohydroxy | 2.67 | 7.38 × 10–3 |
| 5-Dodecenoate (12:1n7) | Medium Chain Fatty Acid | 0.31 | 2.61 × 10–5 | |
| Choline | Phospholipid Metabolism | 0.48 | 7.05 × 10–4 | |
| Docosahexaenoate (22:6n3) | Polyunsaturated Fatty Acid (n3 and n6) | 0.34 | 2.10 × 10–7 | |
| Eicosapentaenoate (20:5n3) | 0.52 | 4.35 × 10–3 | ||
| Thymine | Nucleotide | Pyrimidine Metabolism | 0.33 | 9.39 × 10–5 |
| Uracil | 0.49 | 1.10 × 10–5 | ||
| 3-Ureidopropionate | 2.39 | 1.09 × 10–4 | ||
| Phenylacetylglycine | Peptide | Acetylated Peptides | 0.54 | 9.80 × 10–3 |
| Gamma-glutamylglycine | Gamma-glutamyl Amino Acid | 1.67 | 5.53 × 10–3 | |
| p-Aminobenzoate | Xenobiotics | Benzoate Metabolism | 0.45 | 3.50 × 10–3 |
| 3-hydroxyhippurate | 1.72 | 6.75 × 10–3 |