Table 3.
Association of early menopause and all-cause mortality by Cox proportional hazard regression models.
| Groups | Model la HR | P value | C-index | Model IIb HR | P value | C-index | Model IIIc HR | P value | C-index |
|---|---|---|---|---|---|---|---|---|---|
| Women with natural menopause | |||||||||
| Natural menopause at age ≧45 | Ref (1.00) | Ref (1.00) | Ref (1.00) | ||||||
| Early natural menopause | 1.26 (1.03–1.55) | 0.025 | 0.75 (0.72–0.77) | 1.19 (0.97–1.45) | 0.101 | 0.76 (0.74–0.78) | 1.23 (1.00–1.51) | 0.048 | 0.79 (0.78–0.80) |
| Women with surgical menopause | |||||||||
| Surgical menopause at age ≧45 | Ref (1.00) | Ref (1.00) | Ref (1.00) | ||||||
| Early surgical menopause | 1.14 (0.85–1.52) | 0.379 | 0.73 (0.69–0.78) | 1.51 (1.13–2.01) | 0.005 | 0.78 (0.75–0.82) | 1.46 (1.09–1.97) | 0.012 | 0.81 (0.78–0.84) |
a
Adjusted for CKD stage.
b
Adjusted for age, race/ethnicity, and CKD stage.
c
Adjusted for age, race/ethnicity, CKD stage, marital status, smoke, alcohol use, obesity, triglycerides (mg/dl), total cholesterol (mg/dl), HDL-cholesterol (mg/dl), hypertension, diabetes, coronary heart disease, congestive heart failure, stroke, cancer.