Table 5.
Association of early menopause and all-cause mortality by Cox proportional hazard regression models among the non-CKD group.
| Groups | Model Ia HR | P value | C-index | Model IIb HR | P value | C-index | Model IIIc HR | P value | C-index |
|---|---|---|---|---|---|---|---|---|---|
| Women with natural menopause | |||||||||
| Natural menopause at age ≧45 | Ref (1.00) | Ref (1.00) | Ref (1.00) | ||||||
| Early natural menopause | 1.28 (0.93–1.76) | 0.123 | 0.65 (0.61–0.69) | 1.22 (0.89–1.68) | 0.226 | 0.72 (0.69–0.76) | 1.12 (0.801–1.55) | 0.495 | 0.74 (0.71–0.78) |
| Women with surgical menopause | |||||||||
| Surgical menopause at age ≧45 | Ref (1.00) | Ref (1.00) | Ref (1.00) | ||||||
| Early surgical menopause | 1.44 (0.95–2.17) | 0.087 | 0.61 (0.54–0.69) | 1.67 (1.10–2.53) | 0.015 | 0.73 (0.67–0.79) | 1.62 (1.06–2.49) | 0.027 | 0.78 (0.73–0.83) |
a
Adjusted for eGFR and UACR.
b
Adjusted for age, race/ethnicity, eGFR, and UACR.
c
Adjusted for age, race/ethnicity, eGFR, UACR, marital status, smoke, alcohol use, obesity, triglycerides (mg/dl), total cholesterol (mg/dl), HDL-cholesterol (mg/dl), hypertension, diabetes, coronary heart disease, congestive heart failure, stroke, cancer.