Fig. 5.

Hyaluronic acid (HA) and polyethylene glycol-decorated copper-based nanozymes (Cu_2−xS) enhanced CAR-T cell therapy. Copper-based nanozymes with HA modification on the surface are targeted to tumor cells and react with endogenous H₂O₂ which can be transformed to OH^. through POD-like activity. High local ROS levels caused apoptosis, leading to the release of TAAs. CAR-T cells were engineered to recognize tumor-specific antigens; thus, the combination of nanozyme-based therapy and photothermal therapy (PTT) with CAR-T cells enhanced the tumor infiltration of and function of CAR-T cells.

Reproduced from [51] with permission from Wiley–VCH. Copyright 2021