Fig. 6.

Complex of glucose oxidase (GOx), hemin, and dihydroartemisinic acid (DHA) enveloped in ZIF-8 framework for cancer immunotherapy. Alkylating carbon-centered radical (R^.) and hydroxyl radical (OH^.) were generated by utilizing ROS-generating complexed framework through GOx and Fenton reaction. Elevated ROS levels caused tumor cell death and subsequent release of TAAs which are captured and presented on mature DCs. DCs travel to the lymph node for priming tumor-specific T cells, leading to their infiltration into tumor sites. The combination of the nanozyme platform and anti-PD-L1 therapy increased the efficacy of cancer treatment against primary and distant tumors.

Reproduced from [52] with permission from Wiley–VCH. Copyright 2020