Fig. 7.

Core–shell gold nanocage@manganese dioxide (AuNC@MnO₂) nanozymes for cancer immunotherapy. Under highly acidic condition in the TME, the complex structure was degraded. AuNC@MnO₂ nanozymes are ROS-scavenging nanozymes that produce elevated O₂ levels. Meanwhile, under near-infrared (NIR) irradiation, O₂ was converted into ^.O₂⁻, increasing ROS levels and leading to the induction of ICD. Subsequently, damage-associated molecular patterns (DAMPs; CRT, ATP, HMGB1) released due to ICD trigger DCs maturation and tumor antigen presentation for activating effector T cells against primary tumor and its metastasis.

Reproduced from [53] with permission from Elsevier. Copyright 2018