Table 1.

Recent advances of nanozyme-based enhanced cancer immunotherapy

Nanozyme	Catalytic activity	Synergistic therapy	Therapeutic effects	References
Hyaluronic- and polyethylene glycol-decorated Cu-based nanozymes	POD-like activity	Photothermal therapy (PTT)	Induction of immunogenic death (ICD) to boost the immunological function of effector CAR-T cells	[51]
Glucose oxidase (GOx), hemin, dihydroartemisinic (DHA) enveloped in ZIF-8 framework	GOx activity, POD-like activity	Anti-PD-L1	Formation of elevated ROS to cause tumor cell death, to release TAAs, to enhance infiltration of tumor-specific T cells into tumor site	[52]
Core–shell gold nanocage@manganese dioxide (AuNC@MnO2) nanozyme	CAT-like activity, NIR-mediated conversion of O2 to .O2−	Photodynamic therapy (PDT)	Induction of ICD, release of damage-associated molecular patterns (DAMPs), activation of effector T cells	[53]
Phospholipid-coated Na2S2O8 nanoparticles	Generation of sulfate (.SO4−) and hydroxyl (OH.) radical by dissociation of persulfate	Anti-CTLA-4	High ROS level to induce ICD, release of DAMPs, activation of tumor-specific T cells	[55]
Co-loading of Ce6 and DOX into hollow manganese dioxide (H-MnO2)	CAT-like activity	PDT, chemotherapy, anti-PD-L1	O2 supplement for relief of tumor hypoxia, M2 macrophage polarization, induction of ICD, cytotoxic T lymphocyte CTL) activation	[61]
Combination of CaO2- and MnO2-based nanozymes	H2O2-generating activity, CAT-like activity,	Anti-CTLA-4, chemotherapy	Relief of tumor hypoxia, suppression of Treg activity, activation of CTLs	[63]
Iron- and manganese-based nanozymes encapsuled into mesoporous silica nanoparticles (MSN)	CAT- and POD-like activity	Delivery of TGF-β inhibitor	Relief of tumor hypoxia, M2 macrophage polarization, suppression of Tregs, induction of ICD, activation of effector T cells	[62]