TABLE 2.
Laboratory data of patients according to tertiles of SOFA score at ICU admission.
| SOFA tertile |
|||||||||||||
| All patients | Lower tertile | Middle tertile | Upper tertile | P-value* | |||||||||
| Number of patients | 115 | 49 | 29 | 37 | |||||||||
| WBC count, ×103/μL | 115 | 10735.3 | (5518.2) | 49 | 9897.2 | (4600.9) | 29 | 10903.8 | (6394.6) | 37 | 11713.0 | (5868.5) | 0.195 |
| Hemoglobin, g/dL | 115 | 12.5 | (1.7) | 49 | 12.6 | (1.5) | 29 | 12.3 | (1.9) | 37 | 12.4 | (1.8) | 0.674 |
| MCV, fL | 115 | 89.4 | (12.3) | 49 | 88.3 | (12.5) | 29 | 90.3 | (7.3) | 37 | 90.2 | (15.0) | 0.048 |
| PLT count, ×103/μL | 115 | 260217.4 | (100229.5) | 49 | 285469.4 | (91974.2) | 29 | 241758.6 | (87285.9) | 37 | 241243.2 | (114433.5) | 0.007 |
| Serum glucose, mg/dL | 106 | 156.7 | (61.1) | 45 | 143.4 | (50.5) | 26 | 161.1 | (57.1) | 35 | 170.4 | (73.3) | 0.026 |
| Serum urea, mg/dL | 113 | 56.3 | (45.6) | 48 | 44.2 | (15.5) | 28 | 54.5 | (39.9) | 37 | 73.5 | (66.8) | 0.009 |
| Serum creatinine, mg/dL | 115 | 0.9 | (0.7) | 49 | 0.7 | (0.2) | 29 | 0.9 | (0.4) | 37 | 1.3 | (1.1) | 0.000 |
| Serum sodium, mmol/L | 115 | 137.5 | (4.0) | 49 | 136.9 | (3.2) | 29 | 137.9 | (4.2) | 37 | 137.9 | (4.7) | 0.407 |
| Serum potassium, mmol/L | 115 | 4.0 | (0.5) | 49 | 3.9 | (0.5) | 29 | 3.9 | (0.6) | 37 | 4.1 | (0.6) | 0.108 |
| Serum chloride, mmol/L | 112 | 101.5 | (4.6) | 48 | 100.8 | (3.5) | 27 | 101.6 | (5.3) | 37 | 102.5 | (5.2) | 0.040 |
| Serum calcium, mg/dL | 94 | 8.0 | (0.7) | 40 | 8.2 | (0.6) | 22 | 7.8 | (0.9) | 32 | 7.9 | (0.5) | 0.053 |
| Serum total bilirubin, mg/dL | 107 | 0.9 | (0.5) | 46 | 0.8 | (0.3) | 26 | 1.1 | (0.8) | 35 | 0.9 | (0.5) | 0.689 |
| AST, UI/L | 109 | 79.7 | (99.5) | 47 | 76.3 | (75.5) | 26 | 66.7 | (47.7) | 36 | 93.4 | (145.2) | 0.461 |
| ALT, UI/L | 107 | 67.0 | (75.6) | 47 | 72.9 | (79.4) | 25 | 59.3 | (94.3) | 35 | 64.5 | (54.2) | 0.852 |
| LDH, UI/L | 96 | 602.7 | (218.3) | 43 | 590.4 | (204.2) | 24 | 595.3 | (218.1) | 29 | 627.1 | (243.2) | 0.785 |
| CPK, UI/L | 96 | 313.3 | (820.4) | 41 | 228.2 | (294.8) | 24 | 242.6 | (247.2) | 31 | 480.7 | (1387.8) | 0.229 |
| INR | 109 | 1.4 | (0.3) | 45 | 1.5 | (0.3) | 29 | 1.4 | (0.3) | 35 | 1.4 | (0.3) | 0.053 |
| aPTT ratio | 111 | 1.0 | (0.3) | 46 | 1.0 | (0.2) | 29 | 1.0 | (0.3) | 36 | 1.0 | (0.3) | 0.674 |
| D-Dimer, ng/mL | 102 | 4384.1 | (3395.6) | 47 | 4169.5 | (3242.4) | 25 | 4679.4 | (3353.3) | 30 | 4474.3 | (3743.9) | 0.949 |
| Serum CRP, mg/L | 88 | 160.0 | (81.7) | 43 | 154.9 | (79.0) | 20 | 122.5 | (82.9) | 25 | 198.7 | (71.0) | 0.035 |
| Serum PCT, ng/mL | 113 | 4.2 | (30.3) | 49 | 1.2 | (4.0) | 29 | 1.0 | (1.5) | 35 | 11.0 | (54.2) | 0.012 |
| Serum troponine, ng/L | 98 | 43.9 | (76.1) | 39 | 22.5 | (43.3) | 24 | 62.2 | (112.8) | 35 | 55.3 | (70.1) | 0.000 |
| Arterial blood pH | 115 | 7.4 | (0.1) | 49 | 7.4 | (0.1) | 29 | 7.4 | (0.1) | 37 | 7.3 | (0.1) | 0.005 |
| Partial pressure of O2 in arterial blood, mmHg | 115 | 80.2 | (29.5) | 49 | 76.5 | (28.2) | 29 | 85.0 | (27.8) | 37 | 81.4 | (32.5) | 0.466 |
| Partial pressure of CO2 in arterial blood, mmHg | 115 | 46.5 | (11.1) | 49 | 44.2 | (9.0) | 29 | 47.4 | (13.5) | 37 | 48.9 | (11.2) | 0.036 |
| Bicarbonate concentration in arterial blood, mmol/L | 115 | 24.5 | (4.0) | 49 | 25.1 | (3.0) | 29 | 24.7 | (4.4) | 37 | 23.4 | (4.5) | 0.006 |
| eGFR, mL/min/1.73 m2 | 56 | 85.6 | (13.1) | 26 | 88.5 | (12.0) | 17 | 82.2 | (15.8) | 13 | 84.2 | (10.6) | 0.261 |
| Hypernatremia | 115 | 49 | 29 | 37 | 0.120 | ||||||||
| No | 110 | 95.7% | 49 | 100.0% | 27 | 93.1% | 34 | 91.9% | |||||
| Yes | 5 | 4.3% | 0 | 0.0% | 2 | 6.9% | 3 | 8.1% | |||||
| Hyponatremia | 115 | 49 | 29 | 37 | 0.431 | ||||||||
| No | 94 | 81.7% | 42 | 85.7% | 23 | 79.3% | 29 | 78.4% | |||||
| Yes | 21 | 18.3% | 7 | 14.3% | 6 | 20.7% | 8 | 21.6% | |||||
| Hyperkalemia | 115 | 49 | 29 | 37 | 1.000 | ||||||||
| No | 114 | 99.1% | 49 | 100.0% | 28 | 96.6% | 37 | 100.0% | |||||
| Yes | 1 | 0.9% | 0 | 0.0% | 1 | 3.4% | 0 | 0.0% | |||||
| Hypokalemia | 115 | 49 | 29 | 37 | 0.279 | ||||||||
| No | 97 | 84.3% | 40 | 81.6% | 23 | 79.3% | 34 | 91.9% | |||||
| Yes | 18 | 15.7% | 9 | 18.4% | 6 | 20.7% | 3 | 8.1% | |||||
| Metabolic alkalosis | 115 | 49 | 29 | 37 | 0.650 | ||||||||
| No | 95 | 82.6% | 41 | 83.7% | 25 | 86.2% | 29 | 78.4% | |||||
| Yes | 20 | 17.4% | 8 | 16.3% | 4 | 13.8% | 8 | 21.6% | |||||
| Metabolic acidosis | 115 | 49 | 29 | 37 | 0.104 | ||||||||
| No | 89 | 77.4% | 40 | 81.6% | 25 | 86.2% | 24 | 64.9% | |||||
| Yes | 26 | 22.6% | 9 | 18.4% | 4 | 13.8% | 13 | 35.1% | |||||
Data are expressed as mean (SD), or count and percentage. *P-values refer to tests for trend (Cuzick rank test for continuous variables, Jonckheere–Terpstra test for ordered variables, and exact Cochran–Armitage test for dichotomous variables). ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CPK, creatine phosphokinase; eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; ICU, intensive care unit; INR, international normalized ratio; MCV, mean corpuscular volume; PCT, procalcitonin; PLT, platelet; SOFA, Sequential Organ Failure Assessment; WBC, white blood cell. The bold values indicate that the number of patients for the total population and each tertile of SOFA score that were available for statistical analyses for each variable.