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Different CAR formats. Upper left: 2nd generation CAR format that is approved on the market for T cells. Other CAR designs improve signaling for NK cells, couple CAR expression and activation to transcription factor systems, target a broader pool of antigens or aim to overcome inhibitory signals of the tumor immunosuppressive environment. TF, Transcription factor; aCAR, activating CAR; iCAR, inhibitory CAR.
