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. 2022 Mar 18;12:844144. doi: 10.3389/fonc.2022.844144

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Copyright © 2022 Li, Zhang, Liu, Zhang, Liu, Qi, Zhang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Roles of ITGA5 in immune and metabolism phenotypes in the TCGA cohort. (A) Correlations between ITGA5 and enrichment scores of metabolism-relevant pathways together with the steps of the cancer immune cascades. (B) Heatmap visualized the abundance of infiltrating immune cell populations with different ITGA5 levels, based on the ESTIMATE, the MCPcounter, the ssGSEA, and the TIMER algorithms. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (C) The corrplot of the correlation between ITGA5 expression and macrophage cell level of the ssGSEA. (D) The corrplot of the correlation between ITGA5 expression and macrophage cell level of the TIMER.