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. 2022 Mar 18;12:844144. doi: 10.3389/fonc.2022.844144
MGMT O-6-methylguanine-DNA methyltransferase
TME tumor microenvironment
TAMs tumor-associated macrophages
BBB blood–brain barrier
ITGA5 integrin subunit alpha 5
TCGA The Cancer Genome Atlas
GTEx Genotype-Tissue Expression Project
CGGA Chinese Glioma Genome Atlas
GEO Gene Expression Omnibus
RMA robust multichip average
FPKM fragments per kilobase million
TPM transcripts per kilobase million
OS Overall survival
IF Immunofluorescence
DAPI 4’,6-Diamidino2-phenylindole dihydrochloride
CNV copy number variation
GISTIC Genomic Identification of Significant Targets in Cance
ESTIMATE Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression
TIMER Tumor Immune Estimation Resource
GSVA gene set variation analysis
ssGSEA single sample gene set enrichment analysis
GO Gene Ontology
KEGG Kyoto Encyclopedia of Genes and Genomes
GSEA Gene set enrichment analysis
GDSC Genomics of Drug Sensitivity in Cancer
IC50 half-maximal inhibitory concentration
CHOL cholangiocarcinoma
HNSC head and neck squamous cell carcinoma
KIRC kidney renal clear cell carcinoma
LAML acute myeloid leukemia
LIHC liver hepatocellular carcinoma
PAAD pancreatic adenocarcinoma
TGCT testicular germ cell tumors
LGG lower-grade glioma
GBM glioblastoma multiforme
IDH isocitrate dehydrogenase
ACC adrenocortical carcinoma
BLCA bladder urothelial carcinoma
BRCA breast invasive carcinoma
CESC cervical squamous cell carcinoma and endocervical adenocarcinoma
COAD colon adenocarcinoma
KIRP kidney renal papillary cell carcinoma
LUAD lung adenocarcinoma
LUSC lung squamous cell carcinoma
MESO mesothelioma
OV ovarian serous cystadenocarcinoma
STAD stomach adenocarcinoma
THCA thyroid carcinoma
UCEC uterine corpus endometrial carcinoma
UVM uveal melanoma
JAK Janus kinase
STAT signal transducer and activator of transcription
IL-4 interleukin-4
TTN titin
EGFR epidermal growth factor receptor
PTEN phosphatase and tensin homolog
ATRX alpha-thalassemia/mental retardation syndrome x-linked chromatin remodeler
CIC capicua transcriptional repressor
FUBP1 far upstream element binding protein 1
COL6A3 collagen type VI alpha 3 chain
PD-1 programmed cell death 1
PD-L1 Programmed cell death 1 ligand 1
CTLA-4 cytotoxic T-lymphocyte associated protein 4
FAK focal adhesion kinase
MAPK Mitogen-Activated Protein Kinase
Erk Extracellular Regulated Kinase
PI3-K phosphatidylinositol 3-kinase
Akt protein kinase B
SAPK stress-activated MAP kinases
JNK c-Jun N-terminal kinase
ROC receiver operating characteristic
AUC area under the curves
IDH1 isocitrate dehydrogenase [NADP] cytoplasmic
OBSCN obscurin
Tregs regulatory T cells
TIDE Tumor Immune Dysfunction and Exclusion