MGMT |
O-6-methylguanine-DNA methyltransferase |
TME |
tumor microenvironment |
TAMs |
tumor-associated macrophages |
BBB |
blood–brain barrier |
ITGA5 |
integrin subunit alpha 5 |
TCGA |
The Cancer Genome Atlas |
GTEx |
Genotype-Tissue Expression Project |
CGGA |
Chinese Glioma Genome Atlas |
GEO |
Gene Expression Omnibus |
RMA |
robust multichip average |
FPKM |
fragments per kilobase million |
TPM |
transcripts per kilobase million |
OS |
Overall survival |
IF |
Immunofluorescence |
DAPI |
4’,6-Diamidino2-phenylindole dihydrochloride |
CNV |
copy number variation |
GISTIC |
Genomic Identification of Significant Targets in Cance |
ESTIMATE |
Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression |
TIMER |
Tumor Immune Estimation Resource |
GSVA |
gene set variation analysis |
ssGSEA |
single sample gene set enrichment analysis |
GO |
Gene Ontology |
KEGG |
Kyoto Encyclopedia of Genes and Genomes |
GSEA |
Gene set enrichment analysis |
GDSC |
Genomics of Drug Sensitivity in Cancer |
IC50 |
half-maximal inhibitory concentration |
CHOL |
cholangiocarcinoma |
HNSC |
head and neck squamous cell carcinoma |
KIRC |
kidney renal clear cell carcinoma |
LAML |
acute myeloid leukemia |
LIHC |
liver hepatocellular carcinoma |
PAAD |
pancreatic adenocarcinoma |
TGCT |
testicular germ cell tumors |
LGG |
lower-grade glioma |
GBM |
glioblastoma multiforme |
IDH |
isocitrate dehydrogenase |
ACC |
adrenocortical carcinoma |
BLCA |
bladder urothelial carcinoma |
BRCA |
breast invasive carcinoma |
CESC |
cervical squamous cell carcinoma and endocervical adenocarcinoma |
COAD |
colon adenocarcinoma |
KIRP |
kidney renal papillary cell carcinoma |
LUAD |
lung adenocarcinoma |
LUSC |
lung squamous cell carcinoma |
MESO |
mesothelioma |
OV |
ovarian serous cystadenocarcinoma |
STAD |
stomach adenocarcinoma |
THCA |
thyroid carcinoma |
UCEC |
uterine corpus endometrial carcinoma |
UVM |
uveal melanoma |
JAK |
Janus kinase |
STAT |
signal transducer and activator of transcription |
IL-4 |
interleukin-4 |
TTN |
titin |
EGFR |
epidermal growth factor receptor |
PTEN |
phosphatase and tensin homolog |
ATRX |
alpha-thalassemia/mental retardation syndrome x-linked chromatin remodeler |
CIC |
capicua transcriptional repressor |
FUBP1 |
far upstream element binding protein 1 |
COL6A3 |
collagen type VI alpha 3 chain |
PD-1 |
programmed cell death 1 |
PD-L1 |
Programmed cell death 1 ligand 1 |
CTLA-4 |
cytotoxic T-lymphocyte associated protein 4 |
FAK |
focal adhesion kinase |
MAPK |
Mitogen-Activated Protein Kinase |
Erk |
Extracellular Regulated Kinase |
PI3-K |
phosphatidylinositol 3-kinase |
Akt |
protein kinase B |
SAPK |
stress-activated MAP kinases |
JNK |
c-Jun N-terminal kinase |
ROC |
receiver operating characteristic |
AUC |
area under the curves |
IDH1 |
isocitrate dehydrogenase [NADP] cytoplasmic |
OBSCN |
obscurin |
Tregs |
regulatory T cells |
TIDE |
Tumor Immune Dysfunction and Exclusion |