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. 2022 Apr 1;22(6):781–790. doi: 10.1016/S1473-3099(22)00143-8

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Risk of SARS-CoV-2 infection in individuals with natural immunity compared with individuals without immunity (A), and risk of these outcomes in individuals with one-dose hybrid immunity (B) and two-dose hybrid immunity (C) compared with individuals with natural immunity

The associations were modelled using restricted cubic splines in default positions. The shaded areas show the 95% CI for the hazard ratios. The associations were adjusted for age, baseline date, sex, marital status, homemaker service, place of birth, education, and comorbidities according to table 1.