Table 1.
Baseline characteristics of the three study cohorts
|
Cohort 1* |
Cohort 2† |
Cohort 3‡ |
|||||
|---|---|---|---|---|---|---|---|
| Natural immunity (n=1 019 553) | No immunity (n=1 019 553) | One-dose hybrid immunity (n=481 159) | Natural immunity (n=481 159) | Two-dose hybrid immunity (n=283 905) | Natural immunity (n=283 905) | ||
| Age, years | 39·2 (25·5–53·0) | 39·2 (25·5–53·0) | 39·9 (28·3–52·4) | 39·9 (28·3–52·4) | 37·6 (27·8–50·3) | 37·6 (27·8–50·3) | |
| Sex | |||||||
| Female | 518 515 (50·9%) | 538 766 (52·8%) | 249 461 (51·8%) | 236 717 (49·2%) | 155 634 (54·8%) | 142 285 (50·1%) | |
| Male | 501 038 (49·1%) | 480 787 (47·2%) | 231 698 (48·2%) | 244 442 (50·8%) | 128 271 (45·2%) | 141 620 (49·9%) | |
| Homemaker service recipient§ | 29 381 (2·9%) | 17 582 (1·7%) | 9918 (2·1%) | 7160 (1·5%) | 7881 (2·8%) | 5026 (1·8%) | |
| Born in Sweden | 783 373 (76·8%) | 784 810 (77·0%) | 385 140 (80·0%) | 342 936 (71·3%) | 226 898 (79·9%) | 184 893 (65·1%) | |
| Marital status | |||||||
| Married | 366 339 (35·9%) | 343 165 (33·7%) | 184 948 (38·4%) | 182 237 (37·9%) | 101 445 (35·7%) | 100 150 (35·3%) | |
| Not married | 526 479 (51·6%) | 550 797 (54·0%) | 245 855 (51·1%) | 241 689 (50·2%) | 153 522 (54·1%) | 148 319 (52·2%) | |
| Divorced | 92 143 (9·0%) | 96 537 (9·5%) | 39 973 (8·3%) | 45 249 (9·4%) | 22 323 (7·9%) | 27 293 (9·7%) | |
| Widow or widower | 21 481 (2·1%) | 24 578 (2·4%) | 7715 (1·6%) | 7797 (1·6%) | 5013 (1·8%) | 4995 (1·8%) | |
| Other | 13 111 (1·3%) | 4 476 (0·4%) | 171 (< 0·1%) | 124 (< 0·1%) | 1602 (0·6%) | 3148 (1·1%) | |
| Education | |||||||
| Elementary school for <9 years | 40 311 (4·0%) | 42 264 (4·1%) | 14 197 (3·0%) | 20 180 (4·2%) | 8402 (3·0%) | 13 902 (4·9%) | |
| Elementary school for 9 years | 111 606 (10·9%) | 121 185 (11·9%) | 55 717 (11·6%) | 64 194 (13·3%) | 31 578 (11·1%) | 40 430 (14·2%) | |
| Secondary school for 2 years | 153 336 (15·0%) | 152 925 (15·0%) | 68 252 (14·2%) | 76 798 (16·0%) | 37 324 (13·1%) | 44 952 (15·8%) | |
| Secondary school for >2 years | 243 207 (23·9%) | 226 828 (22·2%) | 125 153 (26·0%) | 126 711 (26·3%) | 77 835 (27·4%) | 78 572 (28·7%) | |
| University | 355 077 (34·8%) | 350 063 (34·3%) | 192 321 (40·0%) | 163 866 (34·1%) | 114 261 (40·2%) | 87 778 (30·9%) | |
| Unknown | 116 016 (11·4%) | 126 288 (12·4%) | 25 519 (5·3%) | 29 410 (6·1%) | 14 505 (5·1%) | 18 281 (6·4%) | |
| Comorbidities | |||||||
| Myocardial infarction | 11 213 (1·1%) | 10 190 (1·0%) | 4358 (0·9%) | 4342 (0·9%) | 2371 (0·8%) | 2433 (0·9%) | |
| Stroke | 11 775 (1·2%) | 9 233 (0·9%) | 4522 (0·9%) | 3659 (0·8%) | 2953 (1·0%) | 2203 (0·8%) | |
| Diabetes | 46 234 (4·5%) | 51 901 (5·1%) | 25 365 (5·3%) | 20 994 (4·4%) | 15 078 (5·3%) | 12 242 (4·3%) | |
| Hypertension | 141 376 (13·9%) | 145 880 (14·3%) | 68 487 (14·2%) | 58 712 (12·2%) | 37 800 (13·3%) | 32 299 (11·4%) | |
| Kidney failure | 9614 (0·9%) | 7950 (0·8%) | 4155 (0·9%) | 3458 (0·7%) | 2531 (0·9%) | 2181 (0·8%) | |
| COPD | 8056 (0·8%) | 6642 (0·7%) | 3098 (0·6%) | 3942 (0·8%) | 1779 (0·6%) | 1809 (0·6%) | |
| Asthma | 67 440 (6·6%) | 65 240 (6·4%) | 31 538 (6·6%) | 27 803 (5·8%) | 19 215 (6·8%) | 16 218 (5·7%) | |
| Depression | 150 177 (14·7%) | 159 270 (15·6%) | 79 151 (16·5%) | 74 956 (15·6%) | 49 747 (17·5%) | 45 273 (15·9%) | |
| Cancer | 24 838 (2·4%) | 24 662 (2·4%) | 10 703 (2·2%) | 9932 (2·1%) | 6036 (2·1%) | 5480 (1·9%) | |
Data are n (%) or median (IQR).
*
Mean baseline date was Jan 1, 2021 (range Jan 25, 2020, to Oct 3, 2021).
†
Mean baseline date was June 7, 2021 (Dec 27, 2020, to Sept 27, 2021).
‡
Mean baseline date was July 9, 2021 (Dec 30, 2020, to Oct 3, 2021).
§
Homemaker services include domestic services provided to individuals (primarily older individuals) who live at home but need help with shopping, cleaning, meal preparation, and similar tasks. COPD=chronic obstructive pulmonary disease.