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. 2022 Mar 31;13(3):288. doi: 10.1038/s41419-022-04744-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Time course of menthol-induced whole-cell currents in 143B and U2OS cells pretreated with either 15 μM AMTB or vehicle. B IC₅₀ values of four osteosarcoma cell lines after incubation with AMTB for 48 h. C Osteosarcoma cells treated with AMTB exhibited crippled ability of colony formation, and both the amount and the size of the colonies were reduced on a dose-dependent manner. The data was compared by one-way ANOVA with Tukey’s multiple comparison test and shown as mean ± s.d. ***P < 0.001. D AMTB suppresses osteosarcoma cell viability in a time- and dose-dependent manner. Osteosarcoma cells were treated with different concentrations of AMTB for indicated time, while cell viability was determined by the MTS assay. The data was compared by two-way ANOVA with Bonferroni test and shown as mean ± s.d. ***P < 0.001. E, F Osteosarcoma cells were treated with various concentrations of AMTB, and their migration ability was assessed by the wound healing assay and the transwell assay. The data was compared by one-way ANOVA with Tukey’s multiple comparison test and shown as mean ± s.d. ***P < 0.001.