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. 2022 Mar 31;5:291. doi: 10.1038/s42003-022-03235-w

Fig. 4. Lock-and-key mechanism of interaction of PID with Fab F240.

Fig. 4

a Bound and unbound F240 superimpose with an 0.65 Å RMSD with 98.2% of equivalent positions overlapping, suggesting a lock-and-key mechanism of binding. b Conformational changes within Fab 3D6 CDR loops upon coordination of the PID peptide. 3D6 unbound and PID-bound structures superimpose with a 0.90 Å RMSD with 98.4% overlap. Ribbon diagrams of unbound Fabs are depicted in cornflower blue, whereas the PID is colored in the dark green, heavy chain in red, and light chain in dark blue.