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. 2022 Mar 31;12:5495. doi: 10.1038/s41598-022-09390-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Smurf2 expression in primary CRC and the long-term outcome based on the Smurf2 expression. Immunohistochemistry analysis for Smad ubiquitination regulatory factor 2 (Smurf 2) expression in (a, b) primary colorectal cancer (CRC). Scale bar = 200 µm (a) and 100 µm (b). (c) Representative images of each score evaluating Smurf2 expression in primary CRC. Scale bar = 200 µm (c). The Kaplan–Meier analysis for (d) overall survival, (e) time to liver metastasis, and (f) time to surgical failure based on the Smad ubiquitination regulatory factor 2 (Smurf 2) expression in primary CRC.