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. 2022 Mar 31;12:5451. doi: 10.1038/s41598-022-09270-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tg4-42 mice display age-related spatial learning deficits in the acquisition training. Homozygous female Tg4-42- and WT mice were tested at 3m (A, B), 7m (C, D) and 12m (E–F). At 3m, escape latencies did not differ significantly between Tg4-42 and WT mice (A). In contrast, 7m (C) and 12m (E) Tg4-42 mice required significantly more time to reach the goal platform than same-aged WT mice. Swimming speed (B, D, F) did not differ between Tg4-42 and WT animals independent of age. Two-way repeated measures ANOVA followed by Bonferroni multiple comparisons; n = 9–14. All Data presented as mean ± S.E.M. ANOVA: ^###p < 0.001; Bonferroni: *p < 0.05, **p < 0.01, ***p < 0.001.