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. 2022 Mar 31;12:5451. doi: 10.1038/s41598-022-09270-1

Figure 3.

Figure 3

Tg4-42 mice show age-dependent deficits in spatial reference memory in the probe trial. Homozygous female Tg4-42 and WT mice were tested at 3m (A–D), 7m (E–H) and 12m (I–L). 3m WT (A) and Tg4-42 mice (B) showed a significant preference for the target quadrant. Time to reach the target did not differ between genotypes at this age (C). In 7m mice, a significant preference for the target quadrant was found in WT mice (E), whereas Tg4-42 mice showed no clear preference for the target quadrant (F). Furthermore, 7m transgenic mice took significantly longer to reach the target than WT mice (G). At 12m only WT mice (I) showed a significant preference for the target quadrant, whereas Tg4-42 animals (J) showed no preference for the target quadrant. Time to reach the target did not differ in this age group (K). Swimming speed did not differ between WT and Tg4-42 mice at any age tested (D, H, L). TQ target quadrant, LQ left quadrant, RQ right quadrant, OQ opposite quadrant, m age in months. Quadrant preference: One-way repeated measures ANOVA followed by Bonferroni multiple comparisons; Time to reach the target and Swimming speed: unpaired t-test; n = 9–14. All Data presented as mean ± S.E.M. *p < 0.05, **p < 0.01, ***p < 0.001.