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. 2022 Mar 31;12:5451. doi: 10.1038/s41598-022-09270-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cognitive Score is decreased in Tg4-42 mice. During the acquisition training of the MWM cognitive scores of female 3m (A), 7m (C) and 12m old Tg4-42 (E) were significantly lower than in same-aged WT animals. During the probe trial, 3m old Tg4-42 (B) mice show a similar cognitive score compared to WT mice. In contrast, 7m (D) and 12m old Tg4-42 (F) exhibit significantly reduced cognitive scores in the probe trial. Two-way repeated measures analysis of variance (ANOVA) followed by Bonferroni multiple comparisons. ANOVA: ^#p < 0.05, ^###p < 0.001; Bonferroni: *p < 0.05, **p < 0.01, ***p < 0.001. n = 9–14. Data presented as mean ± SEM.