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. 2022 Mar 31;12:5451. doi: 10.1038/s41598-022-09270-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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¹⁸F-FDG-PET shows decreased metabolic activity in the hippocampus of Tg4-42 mice. (A) Quantification of ¹⁸F-FDG uptake in the hippocampus. ¹⁸F-FDG-uptake in the hippocampus was significantly reduced in 3m and 7m Tg4-42 mice compared to same-aged WT animals. Hypometabolism in Tg4-42 increases age-dependently. (B) Fused ¹⁸F-FDG-PET/MRI of a WT mouse in coronal view. (C) Fused ¹⁸F-FDG-PET/MRI of a 3-month-old Tg4-42 mouse in coronal view with distinctly lower FDG uptake compared to the WT mouse. (D) Fused ¹⁸F-FDG-PET/MRI of a 7-month-old Tg4-42 mouse in coronal view with distinctly lower FDG uptake compared to WT and 3-month-old Tg4-42 mice. One-way-ANOVA; ***p < 0.001; **p < 0.01; *p < 0.05; WT wild-type; m months. A Amygdala, C Cortex, H Hypothalamus, Hc Hippocampus, T Thalamus.