Skip to main content
. 2022 Mar 18;9:850340. doi: 10.3389/fcvm.2022.850340

Table 1.

SIRT3 targets and their biological functions.

Molecular targets Biological function References
FOXO3a, OPA1 Mitochondrial dynamics (43, 44)
OGG1 Mitochondrial DNA repair (40)
MnSOD ROS homeostasis (45)
Ku70 Cell Survival (26)
CypD Mitochondrial structure and function (46)
p53 Glucose metabolism (47)
PDC Glucose metabolism (48)
TCA enzymes (citrate synthase, aconitase, isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase) Glucose metabolism (39, 4952)
ETC enzymes (succinate dehydrogenase, NDUFA9 subunit of complex I) ATP production (37)
HMG Co-A synthase Ketogenesis (53)
Glutamate dehydrogenase Amino acid metabolism (36)