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. 2022 Mar 18;13:857736. doi: 10.3389/fneur.2022.857736

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Copyright © 2022 Nguyen, Nam, Han, Le and Oh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the locomotor activity of mice in an open-field (OF) task. Locomotion impairment was indicated by a significant decrease in the total path length. The values of the BVD_non-GVS group were lower than those of the control group on PODs 3 (p < 0.001, Bonferroni test), 7 (p < 0.001, Bonferroni test), and 14 (p < 0.001, Bonferroni test). GVS improved the total path length during OF activity on PODs 7 (p = 0.031, LSD test) and 14 (p = 0.027, LSD test) (A). The percentage of time spent in the outer zone, which is an indicator of anxiety, did not differ among the three groups (B). Values are indicated as the mean ± SD. Statistical significances were calculated using one-way ANOVA with post-hoc tests. *Significant differences between two groups: * p < 0.05; *** p < 0.001.