TABLE 1.

Comparative in vitro activities against clinical isolates

Organism (no. of isolates) and antibiotic	MIC (μg/ml)a
	MRSA (26)
J-111,347	0.5–4	2	2
J-111,225	0.5–4	2	4
J-114,870	1–4	2	4
J-114,871	0.5–4	2	4
Imipenem	16–128	64	128
Meropenem	8–64	32	64
Biapenem	16–128	64	64
Vancomycin	0.5–2	1	1
Staphylococcus aureus, methicillin susceptible (21)
J-111,347	0.008–0.016	≤0.008	0.016
J-111,225	0.008–0.016	0.016	0.016
J-114,870	0.008–0.016	0.016	0.016
J-114,871	0.008–0.032	0.016	0.016
Imipenem	0.008–0.016	0.016	0.016
Meropenem	0.032–0.125	0.063	0.125
Biapenem	0.016–0.063	0.032	0.063
Ceftazidime	4–8	4	8
Vancomycin	0.5–1	0.5	0.5
Coagulase-negative staphylococci, methicillin resistant (25)
J-111,347	0.125–4	0.5	2
J-111,225	0.125–4	1	4
J-114,870	0.125–4	1	4
J-114,871	0.125–4	1	4
Imipenem	0.125–128	16	128
Meropenem	1–128	16	64
Biapenem	0.5–128	16	128
Ceftazidime	8–>128	64	>128
Vancomycin	0.5–2	1	2
Streptococcus pyogenes (30)
J-111,347	≤0.008	≤0.008	≤0.008
J-111,225	≤0.008	≤0.008	≤0.008
J-114,870	≤0.008	≤0.008	≤0.008
J-114,871	≤0.008	≤0.008	≤0.008
Imipenem	≤0.008	≤0.008	≤0.008
Meropenem	≤0.008	≤0.008	≤0.008
Biapenem	≤0.008	≤0.008	≤0.008
Ceftazidime	0.063–0.125	0.063	0.125
Penicillin G	≤0.008	≤0.008	≤0.008
Vancomycin	0.5	0.5	0.5
Streptococcus agalactiae (24)
J-111,347	0.008–0.016	≤0.008	0.016
J-111,225	0.008–0.016	≤0.008	0.016
J-114,870	0.008–0.016	0.016	0.016
J-114,871	0.008–0.032	0.016	0.016
Imipenem	0.008–0.016	≤0.008	0.016
Meropenem	0.016–0.063	0.032	0.032
Biapenem	0.008–0.032	0.016	0.032
Ceftazidime	0.5–1	0.5	0.5
Penicillin G	0.032–0.125	0.032	0.063
Vancomycin	0.5–1	1	1
Streptococcus pneumoniae, including penicillin-resistant organisms (32)
J-111,347	0.004–0.25	0.008	0.25
J-111,225	0.004–0.25	0.016	0.25
J-114,870	0.004–0.25	0.016	0.25
J-114,871	0.004–0.25	0.016	0.25
Imipenem	0.004–0.25	0.016	0.25
Meropenem	0.008–0.5	0.032	0.5
Biapenem	0.008–0.5	0.016	0.25
Ceftazidime	0.125–16	2	16
Penicillin G	0.008–2	0.125	2
Vancomycin	0.25–0.5	0.5	0.5
Enterococcus faecalis (26)
J-111,347	1–8	2	8
J-111,225	1–16	4	8
J-114,870	1–8	4	8
J-114,871	2–16	4	8
Imipenem	0.5–4	1	4
Meropenem	4–32	8	16
Biapenem	2–16	8	16
Ceftazidime	>128	>128	>128
Ampicillin	0.5–4	1	4
Vancomycin	0.5–4	2	2
Enterococcus faecium (17)
J-111,347	2–>128	32	>128
J-111,225	4–>128	32	>128
J-114,870	4–>128	64	>128
J-114,871	4–>128	64	>128
Imipenem	4–>128	64	>128
Meropenem	16–>128	128	>128
Biapenem	16–>128	>128	>128
Ceftazidime	>128	>128	>128
Ampicillin	1–>128	32	128
Vancomycin	1–4	2	4
Escherichia coli (29)
J-111,347	0.016–0.032	0.016	0.032
J-111,225	0.016–0.063	0.032	0.032
J-114,870	0.016–0.032	0.016	0.016
J-114,871	0.016–0.063	0.032	0.032
Imipenem	0.032–0.125	0.063	0.125
Meropenem	0.016–0.016	0.016	0.016
Biapenem	0.016–0.063	0.032	0.063
Ceftazidime	0.063–16	0.063	0.125
Klebsiella pneumoniae (25)
J-111,347	0.016–0.063	0.032	0.032
J-111,225	0.016–0.063	0.032	0.063
J-114,870	0.016–0.063	0.032	0.063
J-114,871	0.016–0.063	0.032	0.063
Imipenem	0.063–0.5	0.125	0.25
Meropenem	≤0.008–0.032	0.016	0.032
Biapenem	0.032–1	0.063	0.5
Ceftazidime	0.032–4	0.063	0.25
Enterobacter cloacae (27)
J-111,347	0.032–0.5	0.063	0.5
J-111,225	0.032–1	0.063	0.5
J-114,870	0.032–2	0.063	1
J-114,871	0.016–1	0.032	0.5
Imipenem	0.063–1	0.5	1
Meropenem	0.016–4	0.032	2
Biapenem	0.032–2	0.125	1
Ceftazidime	0.125–>128	0.5	>128
Enterobacter aerogenes (23)
J-111,347	0.032–0.5	0.063	0.125
J-111,225	0.032–1	0.125	0.25
J-114,870	0.016–1	0.063	0.25
J-114,871	0.032–1	0.125	0.5
Imipenem	0.25–2	0.5	1
Meropenem	0.032–1	0.063	0.25
Biapenem	0.063–1	0.25	1
Ceftazidime	0.063–>128	0.5	64
Citrobacter freundii (22)
J-111,347	0.016–0.25	0.032	0.25
J-111,225	0.032–0.5	0.063	0.25
J-114,870	0.016–0.5	0.032	0.5
J-114,871	0.016–0.5	0.032	0.5
Imipenem	0.063–1	0.25	1
Meropenem	≤0.008–2	0.016	1
Biapenem	0.032–1	0.125	0.5
Ceftazidime	0.063–>128	0.5	>128
Citrobacter diversus (17)
J-111,347	0.016–0.125	0.032	0.063
J-111,225	0.016–0.25	0.032	0.063
J-114,870	0.016–0.125	0.032	0.063
J-114,871	0.016–0.25	0.032	0.063
Imipenem	0.063–0.5	0.125	0.25
Meropenem	≤0.008–0.5	0.016	0.125
Biapenem	0.016–0.125	0.032	0.125
Ceftazidime	0.032–16	0.063	0.5
Proteus mirabilis (24)
J-111,347	0.063–1	0.125	0.25
J-111,225	0.063–1	0.25	0.5
J-114,870	0.032–1	0.125	0.25
J-114,871	0.063–1	0.25	0.5
Imipenem	0.5–4	2	4
Meropenem	0.032–0.125	0.032	0.063
Biapenem	1–4	2	4
Ceftazidime	0.016–0.063	0.032	0.032
Proteus vulgaris (24)
J-111,347	0.032–0.25	0.125	0.25
J-111,225	0.063–0.5	0.125	0.25
J-114,870	0.032–0.25	0.125	0.25
J-114,871	0.063–0.5	0.125	0.25
Imipenem	0.5–4	2	2
Meropenem	0.032–0.063	0.032	0.063
Biapenem	0.125–2	1	2
Ceftazidime	0.016–16	0.063	4
Providencia rettgeri (25)
J-111,347	0.032–0.25	0.125	0.25
J-111,225	0.032–0.5	0.125	0.25
J-114,870	0.032–0.25	0.125	0.25
J-114,871	0.063–0.5	0.125	0.25
Imipenem	0.25–2	1	2
Meropenem	0.016–0.125	0.032	0.063
Biapenem	0.125–1	0.5	1
Ceftazidime	0.016–0.5	0.032	0.063
Morganella morganii (21)
J-111,347	0.125–1	0.25	0.5
J-111,225	0.125–1	0.5	1
J-114,870	0.25–2	0.5	2
J-114,871	0.125–2	0.25	1
Imipenem	1–4	4	4
Meropenem	0.063–2	0.125	0.125
Biapenem	1–4	1	4
Ceftazidime	0.032–128	0.125	16
Serratia marcescens (28)
J-111,347	0.032–1	0.063	0.5
J-111,225	0.032–1	0.063	0.5
J-114,870	0.063–2	0.063	1
J-114,871	0.032–2	0.063	1
Imipenem	0.125–4	0.25	0.5
Meropenem	0.016–4	0.032	1
Biapenem	0.063–4	0.25	0.5
Ceftazidime	0.063–32	0.125	4
Moraxella catarrhalis (25)
J-111,347	≤0.002–0.008	≤0.008	≤0.008
J-111,225	≤0.002–0.016	≤0.008	≤0.008
J-114,870	≤0.002–0.016	≤0.008	≤0.008
J-114,871	≤0.002–0.016	≤0.008	≤0.008
Imipenem	0.008–0.063	0.032	0.063
Meropenem	0.002–0.004	≤0.008	≤0.008
Biapenem	0.016–0.063	0.032	0.032
Ceftazidime	0.016–0.25	0.063	0.125
Haemophilus influenzae (20)
J-111,347	0.032–0.25	0.063	0.125
J-111,225	0.063–0.5	0.125	0.125
J-114,870	0.063–0.5	0.125	0.125
J-114,871	0.063–0.5	0.125	0.125
Imipenem	0.25–2	1	1
Meropenem	0.032–0.125	0.063	0.063
Biapenem	0.25–4	1	1
Ceftazidime	0.032–0.25	0.125	0.125
Ampicillin	0.125–64	0.25	1
Pseudomonas aeruginosa, imipenem susceptible (MIC, ≤4) (34)
J-111,347	0.125–8	0.5	4
J-111,225	0.125–16	1	4
J-114,870	0.125–8	1	4
J-114,871	0.125–8	1	4
Imipenem	0.5–4	2	4
Meropenem	0.125–16	1	4
Biapenem	0.25–4	1	2
Ceftazidime	0.5–>128	1	16
Pseudomonas aeruginosa, imipenem resistant (MIC, ≥8) (38)
J-111,347	1–16	4	8
J-111,225	2–32	8	16
J-114,870	1–32	4	16
J-114,871	2–64	8	16
Imipenem	8–128	16	32
Meropenem	8–128	8	16
Biapenem	1–>128	8	16
Ceftazidime	1–>128	8	128
Acinetobacter spp. (21)
J-111,347	≤0.008–0.25	0.032	0.125
J-111,225	≤0.008–0.5	0.032	0.125
J-114,870	0.032–0.5	0.063	0.25
J-114,871	0.016–0.5	0.032	0.125
Imipenem	0.016–0.25	0.125	0.125
Meropenem	0.032–0.25	0.125	0.25
Biapenem	0.016–0.25	0.125	0.25
Ceftazidime	0.5–32	2	8
Burkholderia cepacia (21)
J-111,347	0.25–16	8	16
J-111,225	0.5–32	8	16
J-114,870	0.5–16	8	16
J-114,871	0.5–32	8	32
Imipenem	0.5–16	4	16
Meropenem	0.032–8	1	4
Biapenem	0.125–8	2	8
Ceftazidime	0.5–>128	2	16
Bacteroides fragilis (22)
J-111,347	0.125–0.5	0.25	0.5
J-111,225	0.25–1	0.25	0.5
J-114,870	0.125–1	0.25	0.5
J-114,871	0.25–1	0.25	0.5
Imipenem	0.063–2	0.5	0.5
Meropenem	0.063–4	0.25	0.25
Biapenem	0.125–4	0.25	0.5
Ceftazidime	4–>128	16	>128
Clostridium difficile (21)
J-111,347	0.5–1	1	1
J-111,225	1–2	2	2
J-114,870	1–2	2	2
J-114,871	1–2	2	2
Imipenem	4–16	8	8
Meropenem	0.5–4	1	2
Biapenem	4–16	8	16
Ceftazidime	32–>128	128	>128

^aDetermined by the broth microdilution method.