TABLE 1.
Top 30 hit compounds from the bioactive high throughput screen with high SSMD and BHS (ranked by BHS).
| Compound name | SSMD | Brain health score | p-value | Selleckchem ID | Mechanism of action |
|---|---|---|---|---|---|
| Dimesna | 1.4201 | 1.8829 | 0.0120 | S1201 | Inactivation of acrolein |
| AT9283 | 0.8713 | 1.4271 | 0.0134 | S1134 | JAK2/3 kinase inhibitor |
| Deferasirox | 1.3424 | 1.4235 | 0.0152 | S1712 | Iron chelator |
| Etodolac | 0.9883 | 1.3901 | 0.0155 | S1328 | COX inhibitor |
| Rapamycin | 1.6795 | 1.3652 | 0.0165 | S1039 | mTOR inhibitor |
| AG-490 (Tyrphostin B42) | 0.7901 | 1.3311 | 0.0167 | S1143 | EGFR inhibitor |
| Budesonide | 0.6488 | 1.3074 | 0.0170 | S1286 | Glucocorticoid steroid |
| Prednisolone | 1.2094 | 1.2636 | 0.0171 | S1737 | Glucocorticoid steroid |
| Nepafenac | 0.7728 | 1.2268 | 0.0176 | S1255 | COX inhibitor |
| Sophocarpine | 0.8636 | 1.2109 | 0.0176 | S2405 | Tetracyclic quinolizidine alkaloid |
| Ganetespib (STA-9090) | 0.8437 | 1.1885 | 0.0203 | S1159 | HSP90 inhibitor |
| Aliskiren Hemifumarate | 1.5401 | 1.1308 | 0.0205 | S2199 | Direct renin inhibitor |
| Olmesartan Medoxomil | 1.6489 | 1.1136 | 0.0208 | S1604 | Angiotensin II receptor blocker |
| Aloperine | 1.0303 | 1.0835 | 0.0210 | S2420 | PI3K/Akt inhibitor |
| SGC-CBP30 | 2.3118 | 1.0794 | 0.0222 | S7256 | CREBBP inhibitor |
| LY2608204 | 1.1448 | 1.0579 | 0.0238 | S2155 | Glucokinase activator |
| Hexstrol | 0.7018 | 1.0509 | 0.0241 | S2473 | Nonsteroidal estrogen |
| Gallamine triethiodide | 0.6848 | 1.0341 | 0.0336 | S2471 | Cholinergic receptor blocker |
| IWR-1-endo | 2.1948 | 0.9941 | 0.0342 | S7086 | Wnt inhibitor |
| Cyproterone Acetate | 1.0325 | 0.9849 | 0.0365 | S2042 | Androgen receptor antagonist |
| Maprotiline HCl | 1.2404 | 0.8950 | 0.0375 | S2517 | Noradrenalin reuptake inhibitor |
| CYT387 | 1.0129 | 0.8683 | 0.0430 | S2219 | JAK1/2 kinase inhibitor |
| Teniposide | 6.8325 | 0.8597 | 0.0403 | S1787 | DNA topoisomerase II inhibitor |
| Volasertib (BI 6727) | 1.3177 | 0.8468 | 0.0411 | S2235 | Plk1 inhibitor |
| Vismodegib | 1.4720 | 0.7387 | 0.0417 | S1082 | Hedgehog inhibitor |
| SB590885 | 1.6987 | 0.7384 | 0.0423 | S2220 | B-raf inhibitor |
| Protionamide | 1.6363 | 0.7103 | 0.0432 | S1881 | Class 1A anti-arrhythmic, Sodium Channel Blocker |
| Y-27632 | 4.8342 | 0.6942 | 0.0433 | S1049 | ROCK1 inhibitor |
| NMDA (N-Methyl-d-aspartic acid) | 1.6915 | 0.6197 | 0.0436 | S7072 | NMDA agonist |
| Mestranol | 1.6959 | 0.5421 | 0.0447 | S2125 | Estrogen receptor activation |