Table 2.
Significant differences in soluble mediators of inflammation between PLWH with and without AUD by HCV co-infection.
| Soluble mediators | Comparison Cohorts | Lower 95% CI (adjusted) | Upper 95% CI (adjusted) | p-value (adjusted) |
|---|---|---|---|---|
| Log2 sCD163 | W0: AUD+/HCV+ vs PLWH Ref. | 0.3404 | 1.3601 | 0.0001 |
| W0: AUD+/HCV- vs PLWH Ref. | 0.0151 | 0.8272 | 0.0379 | |
| W4: AUD+/HCV+ vs PLWH Ref. | 0.6300 | 1.6497 | <0.0001 | |
| W4: AUD+/HCV- vs PLWH Ref. | 0.0911 | 0.9032 | 0.0081 | |
| W0-W4: AUD+/HCV+ | -0.9279 | 0.3488 | 0.7202 | |
| W0-W4: AUD+/HCV- | -0.5422 | 0.3902 | 0.9914 | |
| Log2 LBP | W0: AUD+/HCV+ vs PLWH Ref. | 0.0470 | 1.0401 | 0.0243 |
| W0: AUD+/HCV- vs PLWH Ref. | -0.0189 | 0.7720 | 0.0702 | |
| W4: AUD+/HCV+ vs PLWH Ref. | -0.0327 | 0.9605 | 0.0794 | |
| W4: AUD+/HCV- vs PLWH Ref. | 0.0455 | 0.8364 | 0.0206 | |
| W0-W4: AUD+/HCV+ | -0.5421 | 0.7014 | 0.9966 | |
| W0-W4: AUD+/HCV- | -0.5185 | 0.3896 | 0.9950 | |
| Log2 HEK Blue | W0: AUD+/HCV+ vs PLWH Ref. | 0.6052 | 1.9415 | <0.0001 |
| W0: AUD+/HCV- vs PLWH Ref. | 0.1718 | 1.2629 | 0.0036 | |
| W4: AUD+/HCV+ vs PLWH Ref. | 0.1035 | 1.4398 | 0.0149 | |
| W4: AUD+/HCV- vs PLWH Ref. | -0.0434 | 1.0477 | 0.0868 | |
| W0-W4: AUD+/HCV+ | -0.2969 | 1.3003 | 0.4144 | |
| W0-W4: AUD+/HCV- | -0.3681 | 0.7984 | 0.8453 |
Bold values identify statistically significant comparisons.