Table 2.
H4R Expression According to Different Clinicopathological Parameters in TNBC Patients.
| Clinicopathological Parameter | H4R Expression | ||||
|---|---|---|---|---|---|
| Tumor Score |
Peritumoral Score |
||||
| Median (IQR) | p Value | Median (IQR) | p Value | ||
| Tumor focality | Unifocal | 50 (12.5–95) | NS | 60 (7.5–160) 5 (0–17.5) |
0.011 |
| Multifocal | 0 (0–80) | ||||
| Histologic grade | High | 40 (0–82.5) | NS | 10 (5–125) 17.5 (1–140) |
NS |
| Low | 35 (0–142.5) | ||||
| LN metastases | No | 50 (3.7–105) | NS | 80 (5–160) 10 (1–48.7) |
NS |
| Yes | 25 (0–72.5) | ||||
| Ki67 | ≤20% | 50 (15–110) | NS | 140 (62.5–170) 10 (5–55) |
NS |
| >20% | 40 (0–87.5) | ||||
| Tumor size | >2 cm | 35 (0–115) | NS | 10 (5–35) 100 (5–160) |
NS |
| ≤2 cm | 45 (0–80) | ||||
Abbreviations: H4R, histamine H4 receptor; LN, lymph node; NS, not significant; IQR, interquartile range; TNBC, Triple-negative breast cancer.
Mann–Whitney’s test.