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Electron micrograph of HepG2 cells treated with nucleosides. After 14 days of incubation of HepG2 cells with the control (A), 10 μM AZT (B), 50 μM ddI (C), and 10 μM ddC (D), electron microscopy was undertaken (magnification, ×30,000). Disrupted mitochondrial cristae were observed in ddC- and ddI-treated cells.
