Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of effects of anti-HIV nucleoside analogs on treated HepG2 cells
| Effect | Responsea
|
||||
|---|---|---|---|---|---|
| AZT | ddC | d4T | ddI | 3TC | |
| Increased lactic acid levels | ++ | + | − | + | − |
| Mitochondrial morphological changes | Enlarged mitochondria | Loss of crisitae | − | Loss of cristae | − |
| Inhibition of mtDNA | − | +++ | − | ++ | − |
| Inhibition of mitochondrial polypeptides | − | +++ | − | ++ | − |
| Inhibition of COX and citrate synthase | + | − | ND | ND | ND |
ND, not determined.
