Table 2.
Multivariable logistic regression for analyzing the risk factors for brain metastasis from CRC before PSM.
| OR | 95% CI | p ∗ | |
|---|---|---|---|
| Age (years) | 0.495 | ||
| <50 | 1 | ||
| 50–59 | 1.330 | 0.621–2.850 | |
| 60–69 | 0.927 | 0.421–2.042 | |
| 70–79 | 0.671 | 0.273–1.650 | |
| ≥80 | 1.100 | 0.459–2.637 | |
| Race | 0.170 | ||
| White | 1 | ||
| Black | 0.857 | 0.440–1.671 | |
| Other† | 0.377 | 0.135–1.051 | |
| Gender | 0.598 | ||
| Male | 1 | ||
| Female | 1.138 | 0.705–1.837 | |
| Location | 0.135 | ||
| Right side | 1 | ||
| Left side | 1.085 | 0.630–1.867 | |
| Rectum | 0.553 | 0.280–1.094 | |
| Grade | 0.076 | ||
| Grade I | 1 | ||
| Grade II | 1.546 | 0.368–6.495 | |
| Grade III | 3.425 | 0.779–15.059 | |
| Grade IV | 2.624 | 0.422–16.331 | |
| Unknown | 2.321 | 0.494–10.895 | |
| Histology | 0.293 | ||
| AC | 1 | ||
| MC | 0.202 | 0.028–1.475 | |
| SRCC | 1.607 | 0.367–7.024 | |
| Other | 0.405 | 0.054–3.018 | |
| pT | 0.238 | ||
| T1–2 | 1 | ||
| T3–4 | 0.690 | 0.373–1.278 | |
| Unknown | – | – | |
| pN | 0.048 | ||
| N0–N1b | 1 | ||
| N2a–N2b | 1.760 | 1.006–3.077 | |
| Unknown | – | – | |
| Bone metastasis | <0.001 | ||
| No/Unknown | 1 | ||
| Yes | 4.855 | 2.213–10.654 | |
| Liver metastasis | 0.005 | ||
| No/Unknown | 1 | ||
| Yes | 2.412 | 1.304–4.462 | |
| Lung metastasis | <0.001 | ||
| No/Unknown | 1 | ||
| Yes | 8.786 | 4.868–15.857 | |
| CEA | <0.001 | ||
| Negative/Unknown | 1 | ||
| Positive | 3.037 | 1.746–5.284 | |
| Perineural Invasion | 0.519 | ||
| Not present/Unknown | 1 | ||
| Present | 0.803 | 0.412–1.566 |
AC, adenocarcinoma; MC, Mucinous adenocarcinoma; SRCC, Signet ring cell carcinoma.
∗p-values were calculated by multivariable logistic regression after adjusted by age, gender, race, location, grade, histology, pT, pN, bone metastases, liver metastases, lung metastases, CEA, and perineural invasion.
†Other = American Indian/AK Native, and Asian/Pacific Islander.