Table 3.
Multivariable analyses using Cox models associated with CSS and OS for patients with CRC after PSM.
| CSS | OS | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p ∗ | HR | 95% CI | p ∗ | |
| Brain metastasis | <0.001 | <0.001 | ||||
| None | 1 | 1 | ||||
| Yes | 2.621 | 2.061–3.333 | 2.556 | 2.026–3.225 | ||
| Age(years) | <0.001 | <0.001 | ||||
| <50 | 1 | 1 | ||||
| 50–59 | 1.449 | 1.020–2.058 | 1.464 | 1.038–2.065 | ||
| 60–69 | 1.462 | 1.035–2.066 | 1.470 | 1.049–2.059 | ||
| 70–79 | 1.803 | 1.224–2.656 | 1.963 | 1.352–2.850 | ||
| ≥80 | 3.933 | 2.588–5.975 | 4.231 | 2.827–6.332 | ||
| Race | 0.123 | 0.028 | ||||
| White | 1 | 1 | ||||
| Black | 1.314 | 0.959–1.799 | 1.479 | 1.101–1.986 | ||
| Other† | 1.310 | 0.901–1.905 | 1.225 | 0.843–1.782 | ||
| Gender | 0.345 | 0.121 | ||||
| Male | 1 | 1 | ||||
| Female | 0.900 | 0.724–1.120 | 0.846 | 0.685–1.045 | ||
| Location | 0.31 | 0.039 | ||||
| Right side | 1 | 1 | ||||
| Left side | 0.680 | 0.495–0.934 | 0.752 | 0.557–1.016 | ||
| Rectum | 0.755 | 0.570–1.000 | 0.723 | 0.550–0.951 | ||
| Grade | 0.006 | 0.023 | ||||
| Grade I | 1 | 1 | ||||
| Grade II | 0.554 | 0.249–1.233 | 0.506 | 0.239–1.070 | ||
| Grade III | 0.962 | 0.425–2.179 | 0.797 | 0.370–1.718 | ||
| Grade IV | 0.628 | 0.227–1.742 | 0.480 | 0.180–1.278 | ||
| Unknown | 0.569 | 0.255–1.268 | 0.538 | 0.254–1.142 | ||
| Histology | 0.107 | 0.403 | ||||
| AC | 1 | 1 | ||||
| MC | 0.893 | 0.511–1.558 | 0.865 | 0.509–1.468 | ||
| SRCC | 0.862 | 0.352–2.109 | 0.772 | 0.319–1.868 | ||
| Other | 0.526 | 0.313–0.882 | 0.693 | 0.437–1.098 | ||
| pT | 0.143 | 0.144 | ||||
| T1–2 | 1 | 1 | ||||
| T3–4 | 0.939 | 0.651–1.354 | 1.022 | 0.716–1.458 | ||
| Unknown | 1.229 | 0.885–1.709 | 1.288 | 0.933–1.778 | ||
| pN | 0.149 | 0.114 | ||||
| N0–N1b | 1 | 1 | ||||
| N2a–N2b | 1.446 | 0.968–2.160 | 1.470 | 1.002–2.157 | ||
| Unknown | 1.141 | 0.891–1.460 | 1.130 | 0.890–1.436 | ||
| Bone metastasis | 0.013 | 0.018 | ||||
| No/Unknown | 1 | 1 | ||||
| Yes | 1.459 | 1.083–1.965 | 1.419 | 1.062–1.898 | ||
| Liver metastasis | <0.001 | <0.001 | ||||
| No/Unknown | 1 | 1 | ||||
| Yes | 2.054 | 1.570–2.687 | 1.872 | 1.446–2.422 | ||
| Lung metastasis | 0.033 | 0.076 | ||||
| No/Unknown | 1 | 1 | ||||
| Yes | 1.297 | 1.021–1.647 | 1.233 | 0.979–1.553 | ||
| CEA | 0.316 | 0.261 | ||||
| Negative/Unknown | 1 | 1 | ||||
| Positive | 0.883 | 0.693–1.126 | 0.874 | 0.692–1.105 | ||
| Perineural Invasion | 0.846 | 0.865 | ||||
| Not present/Unknown | 1 | 1 | ||||
| Present | 1.050 | 0.641–1.721 | 1.042 | 0.648–1.676 | ||
| Surgery | 0.023 | 0.018 | ||||
| None/unknown | 1 | 1 | ||||
| Performed | 0.591 | 0.376–0.929 | 0.593 | 0.384–0.914 | ||
| Radiotherapy | 0.123 | 0.224 | ||||
| None/unknown | 1 | 1 | ||||
| Performed | 1.213 | 0.949–1.552 | 1.157 | 0.915–1.463 | ||
| Systematic therapy | 0.034 | 0.019 | ||||
| None | 1 | 1 | ||||
| Before surgery | 0.461 | 0.237–0.896 | 0.460 | 0.239–0.887 | ||
| After surgery | 0.686 | 0.472–0.998 | 0.658 | 0.460–0.940 | ||
AC, adenocarcinoma; MC, Mucinous adenocarcinoma; SRCC, Signet ring cell carcinoma.
∗p-values were calculated by multivariable Cox regression after adjusted by brain metastasis, age, gender, race, location, grade, histology, pT, pN, bone metastasis, liver metastasis, lung metastasis, CEA, and perineural invasion.
†Other = American Indian/AK Native, and Asian/Pacific Islander.