Table 1.
Organic metastases of PTEN-inhibited and -uninhibited B16 cells in wild and PTEN-deficient Balb/c mice.
| Mouse viscera | Mice / PBS ip | Mice / VO-OHpic ip (20 μg/kg) | |||||
|---|---|---|---|---|---|---|---|
| 4T1 / VO-OHpic (nmol/L) | 4T1 / VO-OHpic(nmol/L) | ||||||
| 0 | 200 | 500 | 0 | 200 | 500 | ||
| Liver | NMT | 0 | 3 | 6 | 0 | 3 | 5 |
| MTD (L×W cm2) | 0.32×0.3 | 0.8×0.52 | 0.4×0.5 | 1.23×0.77 | 1.1×1.4 | ||
| Lung | NMT | 5 | 8 | 10 | 3 | 10 | 10 |
| MTD (L×W cm2) | 0.14×0.17 | 0.3×0.17 | 0.93×0.7 | 0.4×0.38 | 1.41×1.25 | 1.35×1.5 | |
| Intestine | NMT | 1 | 2 | 5 | 0 | 6 | 8 |
| MTD (L×W cm2) | 0.33×0.3 | 0.8×1.3 | 1.3×1.2 | 1.4×1.1 | |||
| Kidney | NMT | 0 | 0 | 0 | 0 | 1 | 0 |
| MTD (L×W cm2) | 0.3×0.4 | ||||||
| Spleen | NMT | 0 | 0 | 0 | 0 | 0 | 0 |
| MTD (L×W cm2) | |||||||
| Thymus | NMT | 0 | 0 | 0 | 2 | 3 | |
| MTD (L×W cm2) | 0.3×0.1 | 0.2×0.2 | |||||
| Bladder | NMT | 0 | 0 | 0 | 1 | 2 | |
| MTD (L×W cm2) | 0.2×0.1 | 0.2×0.2 | |||||
| Ovary | NMT | 0 | 0 | 0 | 2 | 3 | |
| MTD (L×W cm2) | 0.3×0.17 | 0.29×0.25 | |||||
Mean tumor diameter (MTD), L (long), W (wide).
The number of metastatic tumors of mice (NMT).