Table 2.
Associations of SNPs of inflammation genes with PFS and OS of advanced lung adenocarcinoma patients treated with EGFR-TKIs.
| Genes | SNPs | PFS* | OS* | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| IL1B | rs16944 | 0.991 (0.846-1.161) | 0.914 | 0.953 (0.784-1.160) | 0.632 |
| IL2 | rs2069762 | 0.971 (0.806-1.168) | 0.753 | 1.022 (0.808-1.294) | 0.853 |
| IL2RA | rs2104286 | 1.155 (0.920-1.451) | 0.214 | 1.011 (0.757-1.350) | 0.941 |
| IL4 | rs2243250 | 1.013 (0.840-1.220) | 0.896 | 1.070 (0.845-1.356) | 0.575 |
| IL6 | rs1800796 | 1.031 (0.846-1.257) | 0.761 | 1.006 (0.782-1.294) | 0.961 |
| IL10 | rs1800896 | 1.076 (0.748-1.547) | 0.695 | 1.311 (0.815-2.109 | 0.264 |
| IL15 | rs10519613 | 1.209 (1.028-1.422) | 0.022 | 1.282 (1.047-1.569) | 0.016 |
| IL17A | rs2275913 | 0.940 (0.800-1.106) | 0.457 | 0.913 (0.744-1.124) | 0.386 |
| IL17F | rs763780 | 1.094 (0.893-1.340) | 0.386 | 1.102 (0.856-1.418) | 0.451 |
| IL17RA | rs4819554 | 1.373 (1.151-1.637) | < 0.001 | 1.319 (1.060-1.641) | 0.013 |
| IL21R | rs3093390 | 0.976 (0.740-1.289) | 0.866 | 0.961 (0.686-1.348) | 0.819 |
| IL23R | rs10889677 | 0.926 (0.771-1.112) | 0.409 | 1.141 (0.905-1.439) | 0.264 |
| IL32 | rs28372698 | 0.894 (0.748-1.069) | 0.218 | 0.866 (0.693-1.081) | 0.203 |
| PTGS2 | rs5275 | 0.871 (0.707-1.073) | 0.194 | 0.911 (0.701-1.184) | 0.485 |
| CXCL8 | rs4073 | 0.944 (0.793-1.124) | 0.515 | 0.898 (0.720-1.120) | 0.341 |
| CCR9 | rs7613548 | 1.172 (0.991-1.386) | 0.069 | 1.049 (0.851-1.292) | 0.655 |
| TNF | rs1800629 | 0.795 (0.611-1.035) | 0.089 | 0.878 (0.628-1.227) | 0.446 |
| AURKA | rs2273535 | 0.919 (0.768-1.100) | 0.356 | 0.862 (0.687-1.081) | 0.198 |
| PIN1 | rs2287839 | 0.893 (0.607-1.314) | 0.566 | 0.770 (0.484-1.226) | 0.271 |
| ITGA2 | rs1126643 | 1.031 (0.861-1.236) | 0.737 | 1.065 (0.853-1.331) | 0.576 |
| IL1R1 | rs2234650 | 0.949 (0.796-1.131) | 0.556 | 0.912 (0.734-1.132) | 0.404 |
| IL1R2 | rs2071008 | 0.950 (0.792-1.140) | 0.581 | 1.010 (0.800-1.274) | 0.936 |
| TGFB1 | rs1800470 | 0.972 (0.815-1.158) | 0.747) | 0.961 (0.774-1.195) | 0.723 |
| AGER | rs2070600 | 1.108 (0.924-1.328) | 0.268 | 1.333 (1.068-1.664) | 0.011 |
| MIF | rs755622 | 1.208 (0.996-1.465) | 0.055 | 1.345 (1.057-1.713) | 0.016 |
| ICAM1 | rs5498 | 0.901 (0.741-1.097) | 0.299 | 1.056 (0.828-1.346) | 0.663 |
| CCR6 | rs3093024 | 1.099 (0.915-1.320) | 0.313 | 0.994 (0.790-1.250) | 0.959 |
| TLR4 | rs1057317 | 0.943 (0.795-1.117) | 0.495 | 1.132 (0.916-1.400) | 0.252 |
| CCR5 | rs1799987 | 1.016 (0.843-1.223) | 0.869 | 1.112 (0.886-1.394) | 0.360 |
| RNASEL | rs486907 | 0.894 (0.741-1.080) | 0.245 | 0.871 (0.687-1.117) | 0.284 |
| IL10RA | rs9610 | 0.892 (0.748-1.063) | 0.202 | 0.936 (0.755-1.160) | 0.545 |
| TNFRSF1B | rs1061624 | 0.947 (0.808-1.109) | 0.497 | 0.906 (0.741-1.107) | 0.333 |
| CAPN10 | rs3792267 | 1.230 (0.968-1.564) | 0.091 | 1.241 (0.912-1.689) | 0.170 |
| CRP | rs1205 | 0.917 (0.777-1.082) | 0.303 | 0.935 (0.760-1.150) | 0.524 |
| NFKB1 | rs28362491 | 1.075 (0.914-1.265) | 0.382 | 1.037 (0.846-1.270) | 0.728 |
| IL21 | rs907715 | 1.026 (0.876-1.201) | 0.752 | 1.064 (0.876-1.293) | 0.531 |
| CSF1R | rs10079250 | 1.100 (0.920-1.314) | 0.295 | 1.172 (0.94-1.470) | 0.171 |
| CCL2 | rs1024611 | 0.975 (0.835-1.138) | 0.745 | 0.918 (0.754-1.117) | 0.391 |
| TREM1 | rs2234246 | 1.120 (0.905-1.387) | 0.299 | 0.970 (0.755-1.246) | 0.811 |
| PTX3 | rs2305619 | 1.014 (0.862-1.193) | 0.865 | 1.124 (0.915-1.380) | 0.267 |
| SOCS1 | rs243327 | 1.144 (0.961-1.362) | 0.131 | 1.215 (0.978-1.509) | 0.079 |
| IFNG | rs2430561 | 0.912 (0.763-1.090) | 0.313 | 0.848 (0.684-1.052) | 0.134 |
| CXCR3 | rs2280964 | 1.024 (0.872-1.202) | 0.772 | 0.947 (0.777-1.155) | 0.591 |
| TNFRSF1A | rs4149570 | 1.342 (1.134-1.587) | 0.001 | 1.328 (1.083-1.627) | 0.006 |
| PTGS1 | rs3842787 | 1.048 (0.810-1.357) | 0.720 | 0.918 (0.682-1.236) | 0.573 |
| PTGIR | rs1126510 | 0.932 (0.738-1.176) | 0.552 | 1.074 (0.813-1.419) | 0.614 |
| ITGB3 | rs2317385 | 1.100 (0.932-1.297) | 0.260 | 1.059 (0.861-1.302) | 0.588 |
CI, confidence interval; HR, hazard ratio; PFS, progression-free survival; OS, overall survival.
Statistically significant values are in bold.
*Adjusted by sex, age, smoking status, ECGO, and TNM stage.