Table 4.
Associations of SNPs and GRS with OS and PFS of advanced lung adenocarcinoma patients treated with EGFR-TKI stratified by sex.
| Sex | SNPs/GRS | PFS* | OS* | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Male | rs10519613 | 1.392 (1.034-1.874) | 0.029 | 1.263 (0.897-1.779) | 0.181 |
| rs4819554 | 1.566 (1.123-2.185) | 0.008 | 1.677 (1.113-2.527) | 0.013 | |
| rs4149570 | 1.747 (1.267-2.410) | 0.001 | 1.613 (1.112-2.340) | 0.012 | |
| rs2070600 | – | 1.399 (0.938-2.087) | 0.099 | ||
| rs755622 | – | 1.699 (1.172-2.463) | 0.005 | ||
| low GRS | 1 | 1 | |||
| Intermediate GRS | 2.016 (1.167-3.482) | 0.012 | 2.984 (1.445-6.159) | 0.003 | |
| high GRS | 3.042 (1.653-5.599) | < 0.001 | 4.466 (2.115-9.430) | < 0.001 | |
| Female | rs10519613 | 1.152 (0.948-1.401) | 0.155 | 1.312 (1.021-1.687) | 0.034 |
| rs4819554 | 1.238 (1.000-1.533) | 0.050 | 1.177 (0.902-1.535) | 0.230 | |
| rs4149570 | 1.172 (0.959-1.433) | 0.122 | 1.123 (0.876-1.439) | 0.361 | |
| rs2070600 | – | 1.289 (0.991-1.676) | 0.059 | ||
| rs755622 | – | 1.194 (0.878-1.624) | 0.258 | ||
| low GRS | 1 | 1 | |||
| Intermediate GRS | 1.288 (0.918-1.808) | 0.143 | 0.834 (0.951-1.525) | 0.834 | |
| high GRS | 1.629 (1.105-2.400) | 0.014 | 1.967 (1.176-3.289) | 0.010 | |
CI, confidence interval; GRS, genetic risk score; HR, hazard ratio; PFS, progression-free survival; OS, overall survival.
*Adjusted by age, smoking status, ECGO and stages.