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. 2022 Mar 18;10:807786. doi: 10.3389/fcell.2022.807786

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Copyright © 2022 Xu, Liu, Chen, Wang, Liu and Yi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic variation and gene expression of RNA m⁵C regulators in ovarian cancer. (A) Genetic alteration frequencies of m⁵C regulators in pan-cancer. (B) Copy number variation of m⁵C regulators in ovarian cancer. (C) Correlation of copy number variations among m⁵C regulators. (D) Principal component analysis for the expression profile of m⁵C regulators to distinguish OVC from HOSE samples in GSE54388 cohort. OVC, ovarian cancer, HOSE, human ovarian surface epithelium. (E) The differential expression analysis of 14 m⁵C regulators between OVC and HOSE samples in three independent GEO cohorts. Up-regulated in OVC: orange; up-regulated in HOSE samples: blue. (F) Correlation between copy number variation and mRNA level of m⁵C regulators. (G) The boxplot of expression of 14 m⁵C regulators in OVC and HOSE samples in GSE27651 cohort.*p < 0.05, **p < 0.01, ***p < 0.001.