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. 2022 Mar 18;10:807786. doi: 10.3389/fcell.2022.807786

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Copyright © 2022 Xu, Liu, Chen, Wang, Liu and Yi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interaction and correlation analysis between RNA m⁵C regulators in ovarian cancer. (A) Correlation of mRNA levels among m⁵C regulators. (B) Protein–protein interaction plot among the 14 m⁵C regulators. (C–J) Correlations between “writers” (NUSN1, NSUN2, NSUN3, NSUN4, NSUN5, NSUN6, NSUN7, TRDMT1) and “erasers” (TET1, TET2, TET3, ALHBK1) at mRNA level (RPKM). (K–M) Differential mRNA levels of “erasers” between amplified type and wild type of “writers” with the highest CNV frequencies (NOP2, NSUN4, and NSUN2).