Figure 9.

CCL18-induced exosomal miR-760 promoted in vivo tumorigenesis by up-regulating the ARF6-mediated Src/PI3K/Akt signaling pathway

(A) Representative images of xenograft tumors excised from nude mice 28 days after subcutaneous inoculation of MCF-7 cells from five groups (Mock, Exo, miR-760 mimics, CCL18, and CCL18 + shARF6, n = 5 in each group). (B) Tumor volumes were measured at 0, 3, 7, 14, and 28 days, respectively. ∗∗p < 0.01, compared with mock; ^##p < 0.01, compared with CCL18. (C) Representative immunohistochemistry images of ARF6, p-AMAP1, E-cadherin, Vimentin, p-Src, p-PI3K, and p-AKT were shown. Scale bars: 50 μm. ∗p < 0.05, ∗∗p < 0.01, compared with mock; ^##p < 0.01, compared with CCL18.