Table 1.
The overview of the trials describing direct transfer of acute stroke patients to angiography suites equipped with flat-detector computed tomography
| |
Ribo et al.
16
|
Jadhav et al.
15
|
Psychogios et al.
14
|
Mendez et al.
17
|
Psychogios et al.
18
|
Bouslama et al.
19
|
Requena et al.
20
|
||
|---|---|---|---|---|---|---|---|---|---|
| General | Type of study | Single-centre observational | Single-centre observational case-control | Single-centre observational | Single-centre observational case-control | Single-centre observational case-control | Single-centre prospective cohort | Single-centre randomized | |
| Study population | Time from symptom onset | ≤4.5 h | ≤6 h | ≤5 h | ≤6 h | ≤6 h | — | ≤6 h | |
| Baseline stroke severity | RACE >4, NIHSS >10 | NIHSS ≥ 9 | NIHSS ≥ 10 | RACE >4 NIHSS > 10 | NIHSS ≥ 10 or ≥7 (from 2017) | — | RACE >4 NIHSS > 10 | ||
| Primary/secondary transports | Both | Secondary | Both | Both | Both | Secondary | Both | ||
| Number of DT patients | 40 | 111 | 30 | 97 | 230 | 61 | 89 | ||
| Number of DT without prior imaging | 11 | 0 | 21 | 27 | 127 | 0 | 19 | ||
| Non-LVO DT patients (%) | 16.4 | 6.3 | 40 | 18.6 | 27.8 | 8.2 | 16.9 | ||
| Imaging protocol | NC FD-CT | Yes | Yes | Yes | Yes | Yes | Yes | Yes | |
| FD-CTA | No | No | LVO detection | No | LVO detection | LVO and collateral status study | No | ||
| Time metrics (min) | Onset to door | DT | 182 | 303 | 105 | 207 | 160 | 227 | 233 |
| Control | 160 | 304 | Unknown | 182 | 129 | 310 | 242 | ||
| Door to groin | DT | 17 | 22 | 21 | 16 | 25 | 33 | 18 | |
| Control | 60 | 81 | 55 | 70 | 60 | 55 | 42 | ||
| Door to reperfusion | DT | 73 | 66 | 65 | 70 | 68 | 85 | 57 | |
| Control | 114 | 125 | 106 | 111 | 102 | 111 | 84 | ||
| Clinical outcomes | Dramatic recovery (%) | DT | 48.6 | — | — | 50.6 | — | — | 33.8 |
| Control | 27.4 | — | — | 31.7 | — | — | 28.8 | ||
| 90 days % mRS 0-2 | DT | 43 | 41 | 58 | 45 | 43 | |||
| Control | — | 44 | — | 28 | 33 | 41 | 27 | ||
| sICH (%) | DT | 5 | 3 | 4 | 2.5 | 7 | 4.1 | 1.4 | |
| Control | 9.6 | 3 | 7 | 7.6 | 5 | 2 | 4.1 | ||
DT, direct transfer to flat detector computed tomography equipped angiography suite; RACE, Rapid Arterial Occlusion Evaluation Scale for Stroke; FD-CTA, flat-detector computed tomography angiography; LVO, large-vessel occlusion; mRS, modified Rankin Scale score; NC FD-CT, non-contrast-enhanced flat-detector computed topography; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage.