Table 2.
Comparison of all leukocyte-derived parameters evaluated in the study according to the outcome of COVID-19 patients in the development cohort.
| Parameters | Survivors (n = 177) | Non-survivors (n = 49) | p value | ||
|---|---|---|---|---|---|
| n of hematological tests = 1151 | n of hematological tests = 468 | ||||
| Median | IQR | Median | IQR | ||
| WBC (×109/L) | 5.73 | 4.67–7.10 | 10.71 | 7.69–14.08 | <0.001 |
| NE (×109/L) | 3.82 | 2.58–5.02 | 9.39 | 6.36–11.80 | <0.001 |
| LY (×109/L) | 1.23 | 1.00–1.63 | 0.84 | 0.69–0.99 | <0.001 |
| MO (×109/L) | 0.50 | 0.40–0.65 | 0.46 | 0.37–0.62 | 0.21 |
| NE (%) | 67.2 | 57.3–72.9 | 86.6 | 81.7–89.3 | <0.001 |
| LY (%) | 21.7 | 17.3–30.2 | 7.4 | 5.8–11.0 | <0.001 |
| MO (%) | 8.9 | 7.3–10.7 | 4.8 | 3.4–6.1 | <0.001 |
| IG (×109/L) | 0.03 | 0.02–0.06 | 0.13 | 0.07–0.34 | <0.001 |
| IG (%) | 0.6 | 0.4–0.9 | 1.5 | 0.8–2.6 | <0.001 |
| HFLC (×109/L) | 0.03 | 0.02–0.05 | 0.04 | 0.03–0.05 | 0.58 |
| HFLC (%) | 0.6 | 0.4–0.9 | 0.4 | 0.2–0.6 | <0.001 |
| NE-SSC (ch) | 151.73 | 148.50–154.90 | 151.08 | 147.31–155.55 | 0.76 |
| LY-X (ch) | 82.00 | 80.50–83.30 | 83.15 | 81.55–84.11 | 0.001 |
| MO-X (ch) | 122.65 | 121.33–124.14 | 124.95 | 123.92–125.98 | <0.001 |
| NE-SFL (ch) | 48.20 | 46.52–49.88 | 50.80 | 49.45–53.73 | <0.001 |
| LY-Y (ch) | 69.83 | 68.30–71.40 | 70.63 | 67.80–72.04 | 0.50 |
| MO-Y (ch) | 110.05 | 107.31–112.77 | 111.75 | 108.24–114.40 | 0.046 |
| NE-FSC (ch) | 84.50 | 82.03–86.29 | 83.95 | 81.88–86.60 | 0.96 |
| LY-Z (ch) | 59.78 | 57.76–60.64 | 58.95 | 57.58–60.37 | 0.31 |
| MO-Z (ch) | 62.50 | 61.40–63.52 | 62.30 | 60.00–63.66 | 0.48 |
IQR, interquartile range; WBC, white blood cells; NE, neutrophils; LY, lymphocytes; MO, monocytes; IG, immature granulocytes; HFLC, highly fluorescent lymphocyte cells; NE-SSC, the lateral scattered light intensity of the NE area on the WBC differential (WDF) scattergram; ch, channel-arbitrary units of light scattering; LY-X, the lateral scattered light intensity of the LY area on the WDF scattergram; MO-X, the lateral scattered light intensity of the MO area on the WDF scattergram; NE-SFL, the fluorescent light intensity of the NE area on the WDF scattergram; LY-Y, the fluorescent light intensity of the LY area on the WDF scattergram; MO-Y, the fluorescent light intensity of the MO area on the WDF scattergram; NE-FSC, the forward-scattered light intensity of the NE area on the WDF scattergram; LY-Z, the forward-scattered light intensity of the LY area on the WDF scattergram; MO-Z, the forward-scattered light intensity of the MO area on the WDF scattergram.